Shawon Md Shajedur Rahman, Falster Michael O, Hsu Benjumin, Yu Jennifer, Ooi Sze-Yuan, Jorm Louisa
Centre for Big Data Research in Health (CBDRH), University of New South Wales (UNSW) Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Centre for Big Data Research in Health (CBDRH), University of New South Wales (UNSW) Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Am J Cardiol. 2023 Jan 15;187:110-118. doi: 10.1016/j.amjcard.2022.10.047. Epub 2022 Nov 29.
Risk profiles are changing for patients who undergo percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). In Australia, little is known of the nature of these changes in contemporary practice and of the impact on patient outcomes. We identified all CABG (n = 40,805) and PCI (n = 142,399) procedures in patients aged ≥18 years in New South Wales, Australia, during 2008 to 2019. Between 2008 and 2019, the age- and gender-standardized revascularization rate increased by 20% (from 267/100,000 to 320/100,000 population) for all revascularizations. The increase in revascularization was particularly driven by a 35% increase (from 194/100,000 to 261/100,000) in PCI, whereas the rate of CABG decreased by 20% (from 73/100,000 to 59/100,000). Mean age and the prevalence of co-morbidities (especially diabetes and atrial fibrillation) increased for patients with PCI in more recent years but remained consistently lower than for patients with CABG. CABGs performed in patients presenting with a non-ST-segment-elevation acute coronary syndrome halved from 34.3% to 18.7% during the study period, whereas PCIs in this group decreased from 36.5% to 29.6%. Risk-adjusted in-hospital mortality decreased by 7.5 deaths/1,000 procedures per month for CABG but remained unchanged for PCI. Risk-adjusted readmission rates were consistently higher for CABG than for PCI and did not change significantly over time. In conclusion, we observed a dramatic shift over time from CABG to PCI as the revascularization procedure of choice, with the patient base for PCI extending to older and sicker patients. There was a large decrease in mortality after CABG, whereas mortality after PCI remained unchanged.
接受经皮冠状动脉介入治疗(PCI)和冠状动脉旁路移植术(CABG)的患者的风险状况正在发生变化。在澳大利亚,对于当代实践中这些变化的性质以及对患者预后的影响知之甚少。我们确定了2008年至2019年期间澳大利亚新南威尔士州年龄≥18岁患者的所有CABG(n = 40,805)和PCI(n = 142,399)手术。2008年至2019年期间,所有血运重建的年龄和性别标准化血运重建率提高了20%(从每10万人267例增至320例)。血运重建的增加尤其由PCI增加35%(从每10万人194例增至261例)推动,而CABG率下降了20%(从每10万人73例降至59例)。近年来,PCI患者的平均年龄和合并症(尤其是糖尿病和房颤)患病率有所增加,但始终低于CABG患者。在研究期间,因非ST段抬高型急性冠状动脉综合征就诊的患者中进行CABG的比例从34.3%降至18.7%,而该组中PCI的比例从36.5%降至29.6%。CABG的风险调整后住院死亡率每月每1000例手术减少7.5例死亡,但PCI保持不变。CABG的风险调整后再入院率始终高于PCI,且随时间未显著变化。总之,我们观察到随着时间的推移,作为首选血运重建手术,从CABG到PCI发生了巨大转变,PCI的患者群体扩展到了年龄更大、病情更重的患者。CABG后的死亡率大幅下降,而PCI后的死亡率保持不变。