Department of Pulmonary Medicine, JIPMER, India.
Department of Pulmonary Medicine, JIPMER, India.
Indian J Tuberc. 2022 Oct;69(4):695-698. doi: 10.1016/j.ijtb.2021.08.005. Epub 2021 Aug 11.
Kikuchi-Fujimoto disease is a benign and self-limiting systemic disorder of unknown aetiology characterised by fever, superficial lymphadenopathy and leukopenia. In highly endemic & low-resource country like India, it is frequently misdiagnosed as tuberculosis.
Both the cases were diagnosed as necrotizing lymphadenitis by fine-needle aspiration cytology. Tuberculin skin prick test (TST) was positive for one case and negative for the other case. Cartridge based nucleic acid amplification test (CBNAAT) from lymph node aspirate was negative for mycobacterium tuberculosis in both the cases, later on histopathology of lymph node showed diagnosis of Kikuchi-Fujimoto disease.
Kikuchi Fujimoto is a self-limiting disease systemic disease of unknown aetiology. A definite diagnosis can be established by incisional/excisional biopsy of the lymph node. When dealing with cases of tubercular lymphadenitis, Kikuchi-Fujimoto disease should be kept as differential diagnosis.
菊池古藤病是一种良性、自限性的全身性疾病,病因不明,其特征为发热、浅表淋巴结病和白细胞减少。在像印度这样的高地方性和资源匮乏的国家,它经常被误诊为结核病。
这两例均通过细针抽吸细胞学诊断为坏死性淋巴结炎。一例结核菌素皮肤试验(TST)阳性,另一例阴性。两例淋巴结抽吸物的基于试剂盒的核酸扩增试验(CBNAAT)均为结核分枝杆菌阴性,随后淋巴结组织病理学显示为菊池古藤病。
菊池古藤病是一种病因不明的自限性全身性疾病。通过淋巴结切开/切除术可明确诊断。在处理结核性淋巴结炎病例时,应将菊池古藤病作为鉴别诊断。