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经导管主动脉瓣植入术患者减少不良事件的新趋势:瓣叶重叠技术:一项横断面研究

A new trend to reduce adverse events in patients undergoing transcatheter aortic valve implantation: cusp overlap technique: a cross sectional study.

作者信息

Güzel Tuncay, Demir Muhammed, Aktan Adem, Arık Baran, Argun Lokman, İldırımlı Kamran, Sütcü Mihriban, Arslan Bayram, Özbek Mehmet, Kılıç Raif, Aslan Burhan, Gitmez Mesut, Karaçalılar Mehmet, Çakır Çayan, Ertaş Faruk

机构信息

Department of Cardiology, Health Science University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Department of Cardiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.

出版信息

Aging Clin Exp Res. 2023 Feb;35(2):375-385. doi: 10.1007/s40520-022-02307-5. Epub 2022 Dec 2.

Abstract

BACKGROUND

Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for the majority of patients at moderate or high surgical risk. However, some complications occur frequently with this procedure. In this study, we aimed to assess whether the cusp-overlap view (COP) technique may be associated with a reduced incidence of some of these complications compared with the classical three-cusp view (TCV) technique.

METHODS

In this single-center, retrospective study we investigated; technical success, postprocedural permanent pacemaker implantation (PPMI), new-onset stroke, pericardial tamponade, arrhythmia development, acute renal failure, major bleeding, major vascular complications, procedure-related coronary obstruction, new-onset left bundle branch block (LBBB), paravalvular leak, peri-procedural myocardial infarction (MI), day of hospitalization, death, and major adverse cardiac and cerebrovascular events (MACCE) were determined as the clinical endpoints.

RESULTS

A total of 281 consecutive patients who met the study criteria and underwent elective or emergency transfemoral TAVI using the self-expandable CoreValve Evolut valve were included. 176 consecutive patients implanted with the classical TCV technique and 105 consecutive patients implanted with the COP technique were compared. Compared with the TCV group, patients in the COP group had lower PPMI (3.8% vs. 10.8%, p = 0.039), in-hospital mortality (1.9% vs. 8.5%, p = 0.018), and 1-year death (4.8% versus 18.8%, p = 0.001), and MACCE rates (12.4% vs 31.3%, p < 0.001).

CONCLUSION

The COP technique may help to reduce the conduction disturbances, PPMI requirement and complication rates that may develop following TAVI. In addition, it is an interesting result that it reduces mortality and MACCE rates in long-term follow-ups.

摘要

背景

经导管主动脉瓣植入术(TAVI)目前是大多数手术风险为中度或高度的患者的首选治疗方法。然而,该手术经常会出现一些并发症。在本研究中,我们旨在评估与传统的三叶瓣视图(TCV)技术相比,瓣叶重叠视图(COP)技术是否可能与某些并发症的发生率降低相关。

方法

在这项单中心回顾性研究中,我们调查了技术成功率、术后永久性起搏器植入(PPMI)、新发中风、心包填塞、心律失常发生、急性肾衰竭、大出血、主要血管并发症、与手术相关的冠状动脉阻塞、新发左束支传导阻滞(LBBB)、瓣周漏、围手术期心肌梗死(MI)、住院天数、死亡以及主要不良心脑血管事件(MACCE),并将其确定为临床终点。

结果

总共纳入了281例符合研究标准并使用自膨胀CoreValve Evolut瓣膜接受择期或急诊经股动脉TAVI的连续患者。比较了176例采用传统TCV技术植入的连续患者和105例采用COP技术植入的连续患者。与TCV组相比,COP组患者的PPMI较低(3.8%对10.8%,p = 0.039)、住院死亡率较低(1.9%对8.5%,p = 0.018)、1年死亡率较低(4.8%对18.8%,p = 0.001)以及MACCE发生率较低(12.4%对31.3%,p < 0.001)。

结论

COP技术可能有助于减少TAVI术后可能出现的传导障碍、PPMI需求和并发症发生率。此外,在长期随访中它能降低死亡率和MACCE发生率,这是一个有趣的结果。

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