心外膜脂肪组织厚度与早期亚临床心肌功能障碍有关，尤其是在 2 型糖尿病患者中：一项病例对照研究。

Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study.

机构信息

Hospital General de Ticomán, Secretaría de Salud Ciudad de México, Mexico City, Mexico.

Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City, Mexico.

出版信息

BMC Cardiovasc Disord. 2022 Dec 2;22(1):514. doi: 10.1186/s12872-022-02944-8.

BACKGROUND

Cardiac myofibrillary dysfunction, which can be measure by echocardiographical strain value, represents an early subclinical manifestation of heart failure. Epicardial Adipose tissue (EAT) is related to low degree inflammation and oxidative damage in the adjacent tissue.

AIM

To explore whether EAT affects early myocardial dysfunction, as assessed strain values.

METHODS

Case-Control design. Patients lacking clinical significant heart failure, thyroid or renal disease or malignant abnormalities were included. Clinical-demographic and biochemical data were collected. EAT and myofibril deformation were measured by echocardiography.

RESULTS

A total of 71 patients were analyzed, and further subdivided according to type 2 Diabetes Mellitus (t2DM). Higher strain value (higher than -22.4%cut-off value) was associated with male sex and higher anthropometric and metabolic risk measures; particularly those with t2DM. Higher EAT was also associated higher strain value (AUC = 0.92 ± 0.06, p = 0.004), and further correlation was evidenced (rho = 0.488, p < 0.001), with significant influence of t2DM.

CONCLUSION

EAT was related to strain value, suggesting the influence of cardiac adipose tissue on the deformability of cardiac myofibril, with a more significant effect in the population with t2DM.

背景

心肌纤维功能障碍可通过超声心动图应变值测量，代表心力衰竭的早期亚临床表现。心外膜脂肪组织（EAT）与相邻组织的低度炎症和氧化损伤有关。

目的

探讨 EAT 是否影响早期心肌功能障碍，即通过应变值评估。

方法

病例对照设计。纳入无临床显著心力衰竭、甲状腺或肾脏疾病或恶性异常的患者。收集临床人口统计学和生化数据。通过超声心动图测量 EAT 和肌纤维变形。

结果

共分析了 71 例患者，并根据 2 型糖尿病（t2DM）进一步细分。较高的应变值（高于-22.4%的截断值）与男性性别和更高的人体测量和代谢风险指标相关；尤其是那些患有 t2DM 的患者。较高的 EAT 也与较高的应变值相关（AUC=0.92±0.06，p=0.004），进一步证明存在相关性（rho=0.488，p<0.001），且在 t2DM 人群中影响更显著。