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全肝血流阻断联合肝右静脉和下腔静脉移植的极限原位肝切除术治疗肝内胆管细胞癌。

Extreme In Situ Liver Surgery Under Total Vascular Exclusion with Right Hepatic Vein and Inferior Vena Cava Grafts for an Intrahepatic Cholangiocarcinoma.

机构信息

Department of Surgery and Liver and Pancreas Transplantation, IMIB-Arrixaca, Virgen de la Arrixaca Clinic and University, Murcia, Spain.

Department of Anesthesiology, IMIB-Arrixaca, Virgen de la Arrixaca Clinic and University, Murcia, Spain.

出版信息

Ann Surg Oncol. 2023 Feb;30(2):764-765. doi: 10.1245/s10434-022-12787-4. Epub 2022 Dec 3.

Abstract

In this multimedia article, we demonstrate an extreme in situ liver surgery under total vascular exclusion with right hepatic vein and inferior vena cava grafts for an intrahepatic cholangiocarcinoma in a centre with experience in highly complex hepatobiliary surgery and liver transplantation. This surgical approach after neoadjuvant chemotherapy provides an opportunity for surgical salvage in patients with large tumors invading the hepatocaval confluence. This patient was considered unresectable at another hospital and referred to our unit. We performed an accurate preoperative assessment with new generation 3D modelling to plan the type of vascular reconstruction that would allow adequate hepatic venous outflow and the volume of the future liver remnant sufficient to avoid postoperative liver failure. For hemodynamic management of the patient, we performed a total hepatic vascular exclusion with veno-venous bypass without intraoperative adverse events. We used a cryopreserved carotid artery graft after previously planning the most appropriate diameter and length for right hepatic vein reconstruction. The inferior vena cava was reconstructed with gore-tex graft. During the hospital stay there were no postoperative complications. The patient is free of disease. We conclude that patients with advanced malignant liver disease should always be referred to highly specialized liver surgery centers to assess the most appropriate oncological management and the possibility of surgical resectability.

摘要

在这篇多媒体文章中,我们展示了在有丰富复杂肝胆手术和肝移植经验的中心,在完全血管阻断下使用右肝静脉和下腔静脉移植物进行原位肝切除术的一个极端案例,该手术适用于经新辅助化疗后侵犯肝静脉汇合部的大型肿瘤患者的手术挽救。该患者在另一家医院被认为无法切除,转至我们科室。我们使用新一代 3D 建模进行了精确的术前评估,规划了血管重建的类型,以确保足够的肝静脉流出和足够的未来剩余肝脏体积,避免术后肝功能衰竭。为了患者的血流动力学管理,我们进行了全肝血管阻断伴静脉-静脉转流,术中无不良事件发生。我们使用预先规划好的最适合右肝静脉重建的冷冻颈动脉移植物。下腔静脉用 gore-tex 移植物重建。患者在住院期间没有出现术后并发症。目前患者无疾病。我们的结论是,晚期恶性肝病患者应始终转至高度专业化的肝脏外科中心,以评估最合适的肿瘤治疗管理和手术可切除性的可能性。

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引用本文的文献

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