Huang Jia-Ting, Mao Yu-Qin
Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China.
Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, China.
Front Oncol. 2022 Nov 16;12:1029033. doi: 10.3389/fonc.2022.1029033. eCollection 2022.
Abnormal metabolic alterations of cancer cells and the host play critical roles in the occurrence and development of tumors. Targeting cancer cells and host metabolism can provide novel diagnosis indicators and intervention targets for tumors. In recent years, it has been found that gut microbiota is involved in the metabolism of the host and cancer cells. Increasingly, gut microbiome and their metabolites have been demonstrated great influence on the tumor formation, prognosis and treatment. Specific gut microbial composition and metabolites are associated with the status of tumor in the host. Interventions on the gut microbiota can exert the protective effects on the tumor, through the manipulation of structure and its related metabolites. This may be the new approach to improve the efficacy of tumor prevention and treatment. Here, we discuss the effects and the underlying mechanisms of gut microbiota and microbial-derived metabolites in tumor progression and treatment.
癌细胞和宿主的异常代谢改变在肿瘤的发生和发展中起关键作用。针对癌细胞和宿主代谢可提供肿瘤的新型诊断指标和干预靶点。近年来，已发现肠道微生物群参与宿主和癌细胞的代谢。越来越多的研究表明，肠道微生物组及其代谢产物对肿瘤形成、预后和治疗有很大影响。特定的肠道微生物组成和代谢产物与宿主肿瘤状态相关。通过操纵肠道微生物群的结构及其相关代谢产物，对其进行干预可对肿瘤发挥保护作用。这可能是提高肿瘤防治效果的新途径。在此，我们讨论肠道微生物群和微生物衍生代谢产物在肿瘤进展和治疗中的作用及潜在机制。
