过敏性结膜炎：特应性皮炎患者复发性单纯疱疹病毒感染的危险因素。

Allergic conjunctivitis: a risk factor for recurrent herpes simplex virus infections in patients with atopic dermatitis.

机构信息

Helsinki University Hospital, Department of Dermatology and Allergology, Meilahdentie 2, 00250 Helsinki, Finland

出版信息

Eur J Dermatol. 2022 Sep 1;32(5):607-614. doi: 10.1684/ejd.2022.4333.

DOI:10.1684/ejd.2022.4333

PMID:36468732

Abstract

BACKGROUND

Patients with atopic dermatitis have an increased risk of herpes simplex virus (HSV) infections.

OBJECTIVES

We carried out a retrospective, cross-sectional study to investigate the association of disease severity, concomitant atopic diseases and filaggrin mutations with the risk of cutaneous HSV infections in 463 patients with atopic dermatitis.

MATERIALS & METHODS: The correlation between predisposing factors and HSV infections was analysed using chi-square and Mann Whitney U-tests, and the relationship was further studied with binomial logistic regression to ascertain odds ratios.

RESULTS

Allergic conjunctivitis (aOR: 1.770; CI: 1.008-3.109; p = 0.047) and patient age (aOR: 1.022; CI: 1.007-1.036; p = 0.004) showed statistically significant associations with recurrent HSV infections and eczema herpeticum. HSV infections were not linked to severity of atopic dermatitis (p = 0.435) or filaggrin mutation status (p = 0.886).

CONCLUSION

The results highlight the importance for attentiveness of HSV infections in atopic dermatitis patients with concomitant allergic conjunctivitis.

摘要

背景

特应性皮炎患者发生单纯疱疹病毒（HSV）感染的风险增加。

目的

我们开展了一项回顾性、横断面研究，旨在调查 463 例特应性皮炎患者中疾病严重程度、合并特应性疾病和丝聚蛋白突变与皮肤 HSV 感染风险的相关性。

材料和方法

采用卡方检验和曼-惠特尼 U 检验分析易感因素与 HSV 感染之间的相关性，并进一步采用二项逻辑回归分析以确定比值比。

结果

过敏性结膜炎（OR：1.770；95%CI：1.008-3.109；p = 0.047）和患者年龄（OR：1.022；95%CI：1.007-1.036；p = 0.004）与复发性 HSV 感染和疱疹样湿疹有统计学显著关联。HSV 感染与特应性皮炎严重程度（p = 0.435）或丝聚蛋白突变状态（p = 0.886）无关。