定量[锝]锝-亚甲基二膦酸盐单光子发射计算机断层扫描/计算机断层扫描与[氟]氟化钠正电子发射断层扫描/计算机断层扫描在前列腺癌骨转移患者中的相关性研究。
Quantitative [Tc]Tc-MDP SPECT/CT correlated with [F]NaF PET/CT for bone metastases in patients with prostate cancer.
作者信息
Tanaka Kenichi, Norikane Takashi, Mitamura Katsuya, Yamamoto Yuka, Maeda Yukito, Fujimoto Kengo, Takami Yasukage, Ishimura Mariko, Arai-Okuda Hanae, Tohi Yoichiro, Kudomi Nobuyuki, Sugimoto Mikio, Nishiyama Yoshihiro
机构信息
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Department of Clinical Radiology, Kagawa University Hospital, Miki-cho, Kagawa, Japan.
出版信息
EJNMMI Phys. 2022 Dec 5;9(1):83. doi: 10.1186/s40658-022-00513-8.
BACKGROUND
The purpose of the present study was to elucidate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative [Tc]Tc-methylene diphosphonate (MDP) single photon emission computed tomography (SPECT)/CT and [F]-sodium fluoride ([F]NaF) positron emission tomography (PET)/CT in the assessment of bone metastases in patients with prostate cancer.
METHODS
The study included 26 male prostate cancer patients with confirmed or suspected bone metastases who underwent both [Tc]Tc-MDP SPECT/CT and [F]NaF PET/CT studies. Skeletal lesions visible on both SPECT/CT and PET/CT were classified as benign or metastases. The maximum SUV (SUVmax), peak SUV (SUVpeak), mean SUV (SUVmean), metabolic bone volume (MBV), and total bone uptake (TBU) were calculated for every lesion showing abnormal uptake.
RESULTS
A total of 202 skeletal lesions (147 benign and 55 metastases) were detected in the 26 patients. Strong significant correlations were noted between SPECT/CT and PET/CT for the SUV- and volume-based parameters (all P < 0.001). The SUVmax, SUVpeak, SUVmean, and TBU values obtained with SPECT/CT were significantly lower than the corresponding values obtained with PET/CT (all P < 0.001). The MBV in SPECT/CT was significantly higher than that in PET/CT (P < 0.001). All SUV- and volume-based parameters obtained with both SPECT/CT and PET/CT for metastatic lesions were significantly higher than the corresponding parameters for benign lesions (P values from 0.036 to < 0.001).
CONCLUSIONS
These preliminary results demonstrate that the SUV- and volume-based parameters for bone uptake obtained with quantitative SPECT/CT and PET/CT are strongly correlated in patients with prostate cancer. The SUV parameters obtained with SPECT/CT were significantly lower than those obtained with PET/CT, whereas the uptake volume obtained with SPECT/CT was significantly higher than that obtained with PET/CT.
背景
本研究的目的是阐明标准化摄取值（SUV）与通过定量[锝]Tc-亚甲基二膦酸盐（MDP）单光子发射计算机断层扫描（SPECT）/CT和[氟]氟化钠（[F]NaF）正电子发射断层扫描（PET）/CT测量的基于体积的参数在评估前列腺癌患者骨转移中的相关性。
方法
该研究纳入了26例确诊或疑似骨转移的男性前列腺癌患者，他们均接受了[锝]Tc-MDP SPECT/CT和[氟]NaF PET/CT检查。在SPECT/CT和PET/CT上均可见的骨骼病变被分类为良性或转移瘤。对每个显示异常摄取的病变计算最大SUV（SUVmax）、峰值SUV（SUVpeak）、平均SUV（SUVmean）、代谢骨体积（MBV）和总骨摄取量（TBU）。
结果
26例患者共检测到202处骨骼病变（147处良性病变和55处转移瘤）。在基于SUV和基于体积的参数方面，SPECT/CT与PET/CT之间存在强显著相关性（所有P<0.001）。SPECT/CT获得的SUVmax、SUVpeak、SUVmean和TBU值显著低于PET/CT获得的相应值（所有P<0.001）。SPECT/CT中的MBV显著高于PET/CT中的MBV（P<0.001）。SPECT/CT和PET/CT获得的所有转移性病变的基于SUV和基于体积的参数均显著高于良性病变的相应参数（P值从0.036至<0.001）。
结论
这些初步结果表明，定量SPECT/CT和PET/CT获得的骨摄取基于SUV和基于体积的参数在前列腺癌患者中具有强相关性。SPECT/CT获得的SUV参数显著低于PET/CT获得的参数，而SPECT/CT获得的摄取体积显著高于PET/CT获得的摄取体积。
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