Oral Biology Department, Faculty of Dentistry, Tanta university, Egypt; Demonstrator of Oral Biology, Faculty of Dentistry, Tanta University, Tanta, Egypt.
Oral Biology Department, Faculty of Dentistry, Tanta university, Egypt; Professor of Oral Biology, Faculty of Dentistry, Tanta University, Tanta, Egypt.
J Stomatol Oral Maxillofac Surg. 2023 Feb;124(1S):101346. doi: 10.1016/j.jormas.2022.11.022. Epub 2022 Dec 5.
The aim of this study was to compare the effect of using demineralized dentin matrix (DDM) versus hybrid dentin matrices; Demineralized and undemineralized dentin particles (DDM +UDDM) on inducing bone regeneration in mandibular defects.
The study was conducted on fifty adult New Zealand rabbits, twenty for preparation of experimental materials and thirty for surgical procedures. They were randomly assigned into 3 equal groups as follow one control group: no treatment and two experimental groups including demineralized group: treated with DDM only; and hybrid group: treated with a hybrid of (50% DDM+50% UDD). A rounded critical size defect (10 mm in diameter- 5 mm in depth) was created in the body of mandible. After 3- and 6-weeks post-surgery, the bone regeneration was evaluated by light microscope, scanning electron microscope and histomorphometry.
Histological, histomorphometrical observation and SEM revealed that both dentin matrices had largely resorbed and induced new bone formation at both experimental groups compared to the control group, with statistically higher percentage of new bone formation in the hybrid group.
We concluded that although both dentin matrices induced new bone formation; however, hybrid dentin matrix yielded better results compared to DDM group.
本研究旨在比较使用脱矿牙本质基质（DDM）与混合牙本质基质；脱矿和未脱矿牙本质颗粒（DDM+UDDM）对下颌骨缺损诱导骨再生的效果。
本研究在五十只成年新西兰兔上进行，其中二十只为实验材料制备，三十只为手术操作。它们随机分为三组，分别为对照组：无治疗；脱矿组：仅用 DDM 处理；混合组：用（50%DDM+50%UDD）混合处理。在颏体部制造一个圆形临界尺寸缺损（直径 10mm- 深度 5mm）。术后 3 周和 6 周后，通过光镜、扫描电镜和组织形态计量学评估骨再生。
组织学、组织形态计量学观察和 SEM 显示，与对照组相比，两种牙本质基质在实验组中均大量吸收并诱导新骨形成，其中混合组的新骨形成百分比明显更高。
我们得出结论，尽管两种牙本质基质都能诱导新骨形成，但混合牙本质基质的效果优于 DDM 组。
