School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
School of Engineering, IIT Mandi, Mandi, HP, 175075, India.
Pharm Res. 2023 Jan;40(1):307-319. doi: 10.1007/s11095-022-03446-0. Epub 2022 Dec 5.
The probability of agglomerate-to-wall collision was quantified using a unique image processing technique applied to high-speed microscopic images. The study aimed to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates detected within an in-house powder dispersion device.
The device consists of a swirl chamber and two tangential inlets in various configurations, designed to emulate the geometric features of commercial devices such as the Aerolizer® and Osmohaler®. The test cases were conducted with constant flow rates of 30 SLPM and 60 SLPM. Four powder samples were tested, including carrier Respitose® SV010 (median volume diameter 104 µm, span 1.7) and mannitol of three constituent primary particle sizes (3 µm, 5 µm and 7 µm; span 1.6 - 1.9).
At the lower flow rate of 30 SLPM, collision frequencies were significantly different between powders of different constituent particle sizes, but the effects of powder properties diminished on increasing the flow rate to 60 SLPM. At the higher flow rate, all powders experienced a significant increase in the proportion of colliding particles.
Analysis of collision events showed that the probability of collision for each agglomerate increased with agglomerate diameter and velocity. Experimental data of agglomerate-to-wall collision were utilised to develop a logistic regression model that can accurately predict collisions with various powders and flow rates.
使用独特的图像处理技术对高速微观图像进行分析，以量化团聚体与壁面碰撞的概率。本研究旨在探讨在内部粉末分散装置中，流速和颗粒大小对检测到的碰撞团聚体百分比的影响。
该装置由一个旋流室和两个在不同配置下的切向入口组成，旨在模拟 Aerolizer®和 Osmohaler®等商业装置的几何特征。测试案例采用 30 SLPM 和 60 SLPM 两种恒定流速进行。测试了四种粉末样品，包括载体 Respitose®SV010（中值体积直径 104 µm，跨度 1.7）和三种组成初级颗粒大小的甘露醇（3 µm、5 µm 和 7 µm；跨度 1.6-1.9）。
在较低的 30 SLPM 流速下，不同组成颗粒大小的粉末之间的碰撞频率存在显著差异，但在流速增加到 60 SLPM 时，粉末特性的影响减弱。在较高的流速下，所有粉末的碰撞颗粒比例都显著增加。
碰撞事件的分析表明，每个团聚体的碰撞概率随着团聚体直径和速度的增加而增加。利用团聚体与壁面碰撞的实验数据，开发了一个逻辑回归模型，该模型可以准确预测各种粉末和流速下的碰撞。
