Zeng Xiao-Tao, Chen Yan-Yan, Yue Shi-Jun, Xu Ding-Qiao, Fu Rui-Jia, Tang Yu-Ping
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xi'an 712046, China.
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xi'an 712046, China Institute of Integrated Traditional and Western Medicine, Affiliated Hospital of Jiangnan University Wuxi 214062, China.
Zhongguo Zhong Yao Za Zhi. 2022 Oct;47(19):5193-5202. doi: 10.19540/j.cnki.cjcmm.20220511.202.
This study investigated the quality markers(Q-markers) of Euphorbiae Humifusae Herba based on the analytic hierarchy process(AHP)-criteria importance through intercriteria correlation(CRITIC) comprehensive weighting method. The Q-markers evaluation system was constructed based on the AHP-CRITIC comprehensive weighting method with quantitative identification of Q-markers of Euphorbiae Humifusae Herba as the target layer. The index weights of the factor layer and the control layer were integrated based on the weights of three indicators(effectiveness, testability, and specificity) in the factor layer calculated by the AHP method and weights of eight indicators(anti-inflammatory inhibitory rate, coagulation shortening rate, anti-cancer inhibition rate, component degree value, component test batch, component average content, content variation coefficient, and number of medicinal materials retrieved according to components) in the control layer calculated by the CRITIC method. The comprehensive score of the chemical components of Euphorbiae Humifusae Herba was weighted and ranked to identify the Q-markers of Euphorbiae Humifusae Herba. In terms of comprehensive scores, top 10 potential Q-markers of Euphorbiae Humifusae Herba were ranked as cynaroside > quercetin > gallic acid > apigenin > luteolin > apigenin-7-O-glucoside > quercetin-7-O-glucoside > ellagic acid > astragalin > ethyl gallate. This study provides a reference for the quality control of Euphorbiae Humifusae Herba and a methodological reference for the quantitative identification of Q-markers of Chinese medicine.
本研究基于层次分析法（AHP）-标准重要性通过指标间相关性（CRITIC）综合加权法探究了地锦草的质量标志物（Q-标志物）。以地锦草Q-标志物的定量识别为目标层，基于AHP-CRITIC综合加权法构建了Q-标志物评价体系。根据层次分析法计算的因子层中有效性、可测性和专属性三个指标的权重以及CRITIC法计算的控制层中抗炎抑制率、凝血缩短率、抗癌抑制率、成分程度值、成分测试批次、成分平均含量、含量变异系数和按成分检索的药材数量八个指标的权重，对因子层和控制层的指标权重进行整合。对地锦草化学成分的综合得分进行加权排序，以确定地锦草的Q-标志物。就综合得分而言，地锦草前10位潜在Q-标志物的排序为：木犀草苷＞槲皮素＞没食子酸＞芹菜素＞木犀草素＞芹菜素-7-O-葡萄糖苷＞槲皮素-7-O-葡萄糖苷＞鞣花酸＞黄芪苷＞没食子酸乙酯。本研究为地锦草的质量控制提供了参考，也为中药Q-标志物的定量识别提供了方法学参考。
