Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Clin Mol Hepatol. 2023 Feb;29(Suppl):S68-S78. doi: 10.3350/cmh.2022.0358. Epub 2022 Dec 5.
Sarcopenia and nonalcoholic fatty liver disease (NAFLD) are common health problems related to aging. Despite the differences in their diagnostic methods, several cross-sectional and longitudinal studies have revealed the close link between sarcopenia and NAFLD. Sarcopenia and NAFLD are linked by several shared pathogenetic mechanisms, including insulin resistance, hormonal imbalance, systemic inflammation, myostatin and adiponectin dysregulation, nutritional deficiencies, and physical inactivity, thus implicating a bidirectional relationship between sarcopenia and NAFLD. However, there is not sufficient data to support a direct causal relationship between sarcopenia and NAFLD. Moreover, it is currently difficult to conclude whether sarcopenia is a risk factor for nonalcoholic steatohepatitis (NASH) or is a consequence of NASH. Therefore, this review intends to touch on the shared common mechanisms and the bidirectional relationship between sarcopenia and NAFLD.
肌肉减少症和非酒精性脂肪性肝病(NAFLD)是与衰老相关的常见健康问题。尽管它们的诊断方法存在差异,但几项横断面和纵向研究揭示了肌肉减少症和 NAFLD 之间的密切联系。肌肉减少症和 NAFLD 之间存在几种共同的发病机制,包括胰岛素抵抗、激素失衡、全身炎症、肌肉生长抑制素和脂联素失调、营养缺乏和身体活动不足,因此暗示了肌肉减少症和 NAFLD 之间存在双向关系。然而,目前还没有足够的数据支持肌肉减少症和 NAFLD 之间存在直接的因果关系。此外,目前还很难确定肌肉减少症是非酒精性脂肪性肝炎(NASH)的危险因素,还是 NASH 的后果。因此,本综述旨在探讨肌肉减少症和 NAFLD 之间的共同发病机制和双向关系。