Bayard Katherine E, Fabricant Sonya P, White Jessica D, Gordon Brian, Nguyen Brian T
Keck School of Medicine of the University of Southern California; Los Angeles, CA, United States.
Department of Obstetrics and Gynecology, Los Angeles County + University of Southern California Medical Center; Los Angeles, CA, United States.
Contraception. 2023 Mar;119:109913. doi: 10.1016/j.contraception.2022.11.004. Epub 2022 Dec 5.
To evaluate infectious outcomes following postplacental intrauterine device (PPIUD) placement in patients with suspected chorioamnionitis.
This retrospective cohort study identified individuals desiring PPIUD who subsequently developed suspected chorioamnionitis, treated with antibiotics. We followed 12-month infectious outcomes amongst two cohorts: (1) those who received PPIUD and (2) those with placement deferred.
Of 55 followed, 18 of 22 PPIUDs were placed before chorioamnionitis was suspected; 33 placements were deferred. Neither group experienced acute infectious complications. Notably, IUDs were more often deferred when chorioamnionitis was more clearly diagnosed (20/33, 60.6% vs 4/22, 18.2% p < 0.01). Overdiagnosis of chorioamnionitis prevented IUD uptake in 10 of 55 (18.2%) individuals in this sample.
PPIUD placement in individuals with early signs of chorioamnionitis may not result in severe morbidity, in a study limited by sample size. Larger, prospective studies are needed in well-defined cohorts.
Incidental, immediate postplacental IUD placement in individuals with treated, suspected chorioamnionitis was not associated with severe morbidity within 1-year postpartum. Larger-scale, prospective studies are needed to guide the management of incidentally-placed, postplacental IUDs in the setting of mild chorioamnionitis.
评估疑似绒毛膜羊膜炎患者放置胎盘后宫内节育器(PPIUD)后的感染结局。
这项回顾性队列研究纳入了希望放置PPIUD但随后发生疑似绒毛膜羊膜炎并接受抗生素治疗的个体。我们追踪了两个队列在12个月内的感染结局:(1)接受PPIUD放置的患者;(2)推迟放置的患者。
在随访的55例患者中,22例放置PPIUD的患者中有18例在疑似绒毛膜羊膜炎之前放置;33例推迟放置。两组均未出现急性感染并发症。值得注意的是,当绒毛膜羊膜炎诊断更明确时,宫内节育器更常被推迟放置(20/33,60.6%对4/22,18.2%,p<0.01)。在本样本中,55例患者中有10例(18.2%)因绒毛膜羊膜炎的过度诊断而未放置宫内节育器。
在这项受样本量限制的研究中,对有绒毛膜羊膜炎早期迹象的个体放置PPIUD可能不会导致严重发病。需要在明确界定的队列中进行更大规模的前瞻性研究。
对接受治疗的疑似绒毛膜羊膜炎患者在胎盘娩出后立即偶然放置宫内节育器与产后1年内的严重发病无关。需要进行更大规模的前瞻性研究,以指导在轻度绒毛膜羊膜炎情况下偶然放置的胎盘后宫内节育器的管理。