Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; the University of Miami Miller School of Medicine, Miami, Florida; and Einstein Medical Center, Philadelphia, Pennsylvania.
Obstet Gynecol. 2018 Nov;132(5):1211-1221. doi: 10.1097/AOG.0000000000002926.
To compare, using decision analysis methodology, the 1-year probability of pregnancy after intended postplacental intrauterine device (IUD) insertion with intended delayed insertion at an outpatient postpartum visit (delayed postpartum placement).
We developed an evidence-based decision model with the primary outcome of 1-year probability of pregnancy. We compared 1-year probability of pregnancy after intended postplacental or intended delayed postpartum IUD placement. We obtained estimates from the literature for the proportions of the following: mode of delivery, successful IUD placement, IUD type, postpartum visit attendance, IUD expulsion, IUD discontinuation, and contraceptive use, choice, and efficacy after IUD discontinuation. We performed sensitivity analyses and a Monte Carlo simulation to account for variations in proportion estimates.
One-year probabilities of pregnancy among a theoretical cohort of 2,500,000 women intending to receive a postplacental IUD after vaginal birth and 1,250,000 women intending to receive a postplacental IUD after cesarean birth were 17.3% and 11.2%, respectively; the 1-year probability of pregnancy among a theoretical cohort of 2,500,000 women intending to receive a delayed postpartum IUD was 24.6%. For delayed postpartum IUD placement to have effectiveness equal to postplacental placement, 91.4% of women delivering vaginally and 99.7% of women delivering by cesarean would need to attend postpartum care. Once placed, the effectiveness of postplacental IUDs was lower than that of delayed postpartum IUDs: 1-year probabilities of pregnancy after IUD placement at a vaginal birth, cesarean birth, and an outpatient postpartum visit were 15.4%, 6.6%, and 3.9%, respectively.
After accounting for factors that affect successful IUD placement and retention, this decision model indicates that intended postplacental IUD insertion results in a lower 1-year probability of pregnancy as compared with intended delayed postpartum IUD insertion.
使用决策分析方法比较计划产后即刻放置宫内节育器(IUD)与计划在产后门诊延迟放置(产后延迟放置)后 1 年内妊娠的概率。
我们建立了一个基于证据的决策模型,主要结局为 1 年内妊娠的概率。我们比较了计划产后即刻或计划产后延迟放置 IUD 后 1 年内妊娠的概率。我们从文献中获得了以下比例的估计值:分娩方式、IUD 成功放置、IUD 类型、产后就诊率、IUD 脱落、IUD 停用以及 IUD 停用后避孕方法的选择和效果。我们进行了敏感性分析和蒙特卡罗模拟,以考虑比例估计值的变化。
在一个理论上有 250 万例拟经阴道分娩后放置产后即刻 IUD 和 125 万例拟经剖宫产分娩后放置产后即刻 IUD 的妇女队列中,1 年妊娠率分别为 17.3%和 11.2%;在一个理论上有 250 万例拟行产后延迟放置 IUD 的妇女队列中,1 年妊娠率为 24.6%。为了使产后延迟放置 IUD 的效果等同于产后即刻放置,91.4%经阴道分娩的妇女和 99.7%行剖宫产的妇女需要接受产后护理。一旦放置,产后即刻 IUD 的效果低于产后延迟放置 IUD:经阴道分娩、剖宫产和门诊产后放置 IUD 后 1 年妊娠率分别为 15.4%、6.6%和 3.9%。
在考虑了影响 IUD 成功放置和保留的因素后,该决策模型表明,与计划产后延迟放置 IUD 相比,计划产后即刻放置 IUD 导致 1 年内妊娠的概率较低。