Durbin C G, Rosenberg H
J Pharmacol Exp Ther. 1979 Jul;210(1):70-4.
Strandard laboratory rabbits which are not genetically susceptible to malignant hyperpyrexia were anesthetized with either halothane or pentobarbital. Administration of caffeine in 125 mg increments produced a syndrome strongly resembling malignant hyperpyrexia in rabbits anesthetized with halothane. All these animals became rigid, hyperpyrexic, acidotic and hyperkalemic, whereas caffeine-treated, pentobarbital-anesthetized animals developed only mild acidosis. Pentobarbital alone and halothane alone caused no changes in measured variables. This model for malignant hyperpyrexia resembles the naturally occurring disease more closely than several preceding pharmacologic models.
对标准实验室兔子（这些兔子在基因上对恶性高热不敏感）分别用氟烷或戊巴比妥进行麻醉。以125毫克递增剂量给予咖啡因，在氟烷麻醉的兔子身上产生了一种与恶性高热极为相似的综合征。所有这些动物都出现了强直、高热、酸中毒和高钾血症，而用咖啡因处理、戊巴比妥麻醉的动物仅出现了轻度酸中毒。单独使用戊巴比妥和单独使用氟烷对所测量的变量没有产生影响。这种恶性高热模型比之前的几种药理学模型更接近自然发生的疾病。
