为什么双胞胎研究对健康跨度科学研究很重要：以虐待老年人为例。
Why twin studies are important for health span science research: the case of maltreatment of aging adults.
机构信息
The University of Mississippi, University of Mississippi Medical Center, 84 Dormitory Row West, P.O. Box 1848, University, MS, 38677, USA.
Department of Criminal Justice and Criminology, Sam Houston State University, 1905 University Ave, Huntsville, TX, 77341, USA.
出版信息
BMC Geriatr. 2022 Dec 8;22(1):943. doi: 10.1186/s12877-022-03440-6.
Average life expectancies have lengthened across human history. As a result, there is an increased need to care for a greater number of individuals experiencing common age-related declines in health. This has helped to spur a rapidly increasing focus on understanding "health span", the portion of the life-course spent functionally healthy. Yet to penetrate the science of health span, however, is a topic which seems fundamental to the ability to age in functional and healthy ways, and has received considerable attention in other fields. As more of the population ages, the risk of exposure to abuse and neglect among older citizens not only rises, but can manifest as both cause and effect of declining health span. Among our goals here is to make a case for including this subject among the other central components of health span science. In so doing, we also outline reasons why quantitative genetic designs using samples of twins can be a versatile tool for improving causal inference when studying maltreatment among older persons specifically, but also on a range of other health span topics in general.
人类历史上的平均预期寿命一直在延长。因此，需要更多的人来照顾那些健康状况普遍随着年龄增长而下降的人。这有助于促使人们越来越关注理解“健康寿命”，即人们在功能健康状态下度过的生命阶段。然而，要深入研究健康寿命的科学，就必须涉及一个似乎对以功能健康的方式衰老的能力至关重要的话题，这个话题在其他领域也受到了相当多的关注。随着越来越多的人步入老年，老年人遭受虐待和忽视的风险不仅增加了，而且可能成为健康寿命下降的原因和结果。我们的目标之一是将这个话题纳入健康寿命科学的其他核心组成部分。在这样做的过程中，我们还概述了为什么使用双胞胎样本的定量遗传设计可以成为一种通用工具，用于在研究老年人中受虐待的情况时提高因果推断，也可以用于研究一般的其他健康寿命话题。
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