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HIV 照护的新纪元:应对与年龄相关的多种共病

A new era of HIV care for age-associated multimorbidity.

机构信息

Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield.

Academic Unit of Primary Medical Care, The University of Sheffield, Samuel Fox House, Sheffield, UK.

出版信息

Curr Opin Infect Dis. 2023 Feb 1;36(1):9-14. doi: 10.1097/QCO.0000000000000890. Epub 2022 Dec 9.

Abstract

PURPOSE OF REVIEW

The management of people with HIV has shifted focus from acute AIDS-defining illness towards improving detection of chronic disease and reducing impact of multimorbidity. In this review, we explore this shifting paradigm of HIV care and the evidence for alternative models proposed to provide integrated holistic services for people with HIV (PWH) with multimorbidity.

RECENT FINDINGS

Despite 25 years of the antiretroviral treatment (ART) era an increased incidence of noncommunicable disease (NCD) and multimorbidity in PWH persists. As the world moves closer to universal ART coverage this phenomenon is now reported in low- and middle-income settings. Multimorbidity affects PWH disproportionately compared to the general population and results in reduced health related quality of life (HRQoL), greater hospitalization and higher mortality. There is evidence that NCD care provision and outcomes may be inferior for PWH than their HIV negative counterparts. Various models of integrated multimorbidity care have developed and are grouped into four categories; HIV specialist clinics incorporating NCD care, primary care services incorporating HIV care, community NCD clinics offering integrated HIV care, and multidisciplinary care integrated with HIV in secondary care. Evidence is limited as to the best way to provide multimorbidity care for PWH.

SUMMARY

A new era of HIV care for an ageing population with multimorbidity brings challenges for health providers who need to develop holistic patient focused services which span a range of coexisting conditions.

摘要

目的综述

HIV 感染者的管理重点已从急性 AIDS 定义性疾病转移到改善慢性疾病的检测和降低多种合并症的影响。在这篇综述中,我们探讨了 HIV 护理模式的转变,以及为合并多种疾病的 HIV 感染者(PWH)提供综合整体服务而提出的替代模式的证据。

最近的发现

尽管抗逆转录病毒治疗(ART)时代已经过去了 25 年,但 PWH 中非传染性疾病(NCD)和多种合并症的发病率仍在持续上升。随着世界越来越接近普及 ART 覆盖,这种现象现在在中低收入国家也有报道。与一般人群相比,多种合并症对 PWH 的影响更大,导致健康相关生活质量(HRQoL)下降、住院率增加和死亡率升高。有证据表明,NCD 护理的提供和结果可能不如 HIV 阴性患者。已经开发出各种综合多种合并症护理模式,并分为四类:纳入 NCD 护理的 HIV 专科诊所、纳入 HIV 护理的初级保健服务、提供综合 HIV 护理的社区 NCD 诊所以及与二级保健中的 HIV 整合的多学科护理。关于为 PWH 提供多种合并症护理的最佳方式,证据有限。

总结

随着人口老龄化和多种合并症的出现,HIV 护理进入了一个新时代,这给医疗服务提供者带来了挑战,他们需要开发以患者为中心的整体服务,涵盖一系列并存疾病。

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