Computer discriminant analysis of atypical urothelial cells.

Prior computer studies of digitized cell images by the TICAS system have shown that the category of urothelial cells classified visually as atypical may be composed of 2 subgroups, one clustering mainly with benign cells and the other with malignant cells. As a consequence, a visual review of the group of atypical cells was conducted and tested by computer discriminant analysis. The computer classification confirmed the visual reclassification and subdivision of atypical urothelial cells into 2 subgroups, ATY I and ATY II. This is yet another example of feedback from computer diagnosis to visual assessment of cells. The significance of these observations in terms of diagnosis will be the subject of subsequent communications.