van Leeuwen B H, Penschow J D, Coghlan J P, Richards R I
EMBO J. 1987 Jun;6(6):1705-13. doi: 10.1002/j.1460-2075.1987.tb02421.x.
The expression of many mouse kallikrein genes in the salivary gland is sexually dimorphic and inducible in females by administration of testosterone or thyroxine. Induction is slow (3-7 days) and is accompanied by the non-uniform differentiation of the cell type expressing these genes from striated duct (SD) cells (female) to granular convoluted tubule (GCT) cells (male). One kallikrein gene, mGK-6, is expressed at an apparently constant total level in male and female and is not induced by either hormone. In situ hybridization histochemistry shows that all kallikrein genes analyzed exhibit uniform cellular distribution of expression in the SD cells of the female. The hormonally mediated differentiation of some, but not all, of these cells has different effects on kallikrein gene expression--mGK-6 is repressed while other kallikreins are induced--leading to non-uniform distribution of expression.
许多小鼠激肽释放酶基因在唾液腺中的表达具有性别二态性，并且在雌性小鼠中通过给予睾酮或甲状腺素可诱导表达。诱导过程缓慢（3 - 7天），并伴随着表达这些基因的细胞类型从雌性的纹状管（SD）细胞向雄性的颗粒曲管（GCT）细胞的非均匀分化。一个激肽释放酶基因mGK - 6在雄性和雌性小鼠中表达总量明显恒定，且不受任何一种激素诱导。原位杂交组织化学显示，所分析的所有激肽释放酶基因在雌性的SD细胞中均呈现均匀的细胞表达分布。这些细胞中部分（而非全部）细胞的激素介导分化对激肽释放酶基因表达有不同影响——mGK - 6被抑制而其他激肽释放酶被诱导——导致表达分布不均匀。
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