Karin M, Haslinger A, Holtgreve H, Richards R I, Krauter P, Westphal H M, Beato M
Nature. 1984;308(5959):513-9. doi: 10.1038/308513a0.
Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induction by cadmium is duplicated, yet a single copy is fully functional; the element responsible for induction by glucocorticoid hormones is coincident with the DNA-binding site for the glucocorticoid hormone receptor.
缺失实验已经确定了两段DNA（遗传元件），它们靠近人类金属硫蛋白基因的启动子，分别介导该基因被重金属离子（尤其是镉）和糖皮质激素诱导表达。负责镉诱导的元件是重复的，但单拷贝就具有完全功能；负责糖皮质激素诱导的元件与糖皮质激素受体的DNA结合位点重合。
