Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, 37673, Pohang, Kyungbuk, Republic of Korea.
Department of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, 05029, Seoul, Republic of Korea.
Biomaterials. 2023 Jan;292:121941. doi: 10.1016/j.biomaterials.2022.121941. Epub 2022 Dec 3.
Regenerative medicine requires both tissue restoration and ease of compliance for clinical application. Considering this, sticky tissue sealants have been shown to have great potentials over surgical suturing and wound treatment. However, tissue sealants currently used pose challenges such as uncontrollable adhesion formation, mechanical mismatch, and lack of tissue restoration. A new sticky sealant based on gelatinized cornea-derived extracellular matrix (GelCodE) with a visible light-activating system is firstly being introduced in this study. De novo tissue regeneration relies on the matrisome in charge of tissue-organization and development within GelCodE while visible light-based photopolymerization with ruthenium/sodium persulfate rapidly induces covalent bonds with the adjacent tissues. The ease of not only in vivo application, biocompatibility, and biointegration, but also exceptional de novo tissue formation is demonstrated in this study. Interestingly, newly regenerated tissues were shown to have normal tissue-like matrices with little scar formation. Hence, this work presents a promising strategy to meet clinical demands for scar-free tissue recovery with superior ease of clinical application.
再生医学既需要组织修复，也需要便于临床应用。考虑到这一点，粘性组织密封剂在外科缝合和伤口处理方面显示出了巨大的潜力。然而，目前使用的组织密封剂存在一些挑战，如不可控的粘连形成、机械不匹配和缺乏组织修复。本研究首次介绍了一种基于明胶化角膜衍生细胞外基质（GelCodE）的新型粘性密封剂，该密封剂具有可见光激活系统。新组织的再生依赖于 GelCodE 中负责组织组织和发育的基质，而基于可见光的光聚合与钌/过硫酸钠迅速与相邻组织形成共价键。本研究证明了其不仅易于体内应用、生物相容性和生物整合性，而且具有出色的新组织形成能力。有趣的是，新再生的组织具有正常的组织样基质，几乎没有疤痕形成。因此，这项工作提出了一种有前途的策略，以满足临床对无疤痕组织恢复的需求，具有卓越的临床应用便利性。
