Radiotherapy Planning Department, Maria Skłodowska-Curie National Research Institute of Oncology Gliwice Branch, Wybrzeze Armii Krajowej Street 15, 44-102 Gliwice, Poland.
Faculty of Science and Technology, University of Silesia, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland.
Int J Environ Res Public Health. 2022 Dec 1;19(23):16085. doi: 10.3390/ijerph192316085.
The main aim of the study was to compare the temperature response of the body to the dose received during breast cancer radiotherapy. The control group consisted of 50 healthy volunteers. They underwent one thermographic examination and compared the temperatures between the left and right breasts. The research group consisted of 50 patients. Based on the treatment plan, the area PTV and isodose was marked on the thermograms. Five thermographs were performed in each patient (before radiotherapy and in each week of treatment). A qualitatively similar increase in mean temperature during treatment was observed in both subgroups in the analyzed areas. The highest increase in temperature was obtained in the third week of treatment. Compared with the value before treatment, the increase in the mean temperature in PTV in patients after partial surgery was 0.78 °C, these values are statistically significant = 0.000055. In the case of post-mastectomy patients, 0.8 °C was obtained, these values are statistically significant = 0.00369. In addition, strong correlation was calculated between isodoses read from treatment plans and isotherms obtained from the analysis of thermal images. In post-mastectomy patients for PTV r = 0.77, 30 Gy r = 0.94, 20 Gy r = 0.96, and 10 Gy r = 0.75. For patients after partial surgery for PTV r = 0.74, 30 Gy r = 0.89, 20 Gy r = 0.83, and 10 Gy r = 0.89. Infrared thermography seems to be a useful method of assessing the thermal response of the body to the dose received during radiotherapy of breast cancer and may be a clinically useful method of assessing the early skin response to radiation.
本研究的主要目的是比较乳腺癌放疗过程中身体接受剂量的温度反应。对照组由 50 名健康志愿者组成。他们接受了一次热成像检查，并比较了左右乳房之间的温度。研究组由 50 名患者组成。根据治疗计划，在热图像上标记 PTV 和等剂量区。每个患者进行了 5 次热成像检查（放疗前和每周治疗一次）。在分析区域，两个亚组在治疗期间均观察到平均温度的定性相似增加。在治疗的第三周，获得了最高的温度升高。与治疗前的值相比，部分手术后患者 PTV 的平均温度升高了 0.78°C，这些值具有统计学意义 = 0.000055。对于乳房切除术患者，获得了 0.8°C 的升高，这些值具有统计学意义 = 0.00369。此外，还计算了从治疗计划中读取的等剂量与从热图像分析中获得的等温线之间的强相关性。对于乳房切除术患者，PTV 的 r = 0.77、30 Gy 的 r = 0.94、20 Gy 的 r = 0.96 和 10 Gy 的 r = 0.75。对于部分手术后的患者，PTV 的 r = 0.74、30 Gy 的 r = 0.89、20 Gy 的 r = 0.83 和 10 Gy 的 r = 0.89。红外热成像似乎是一种评估乳腺癌放疗过程中身体对剂量的热反应的有用方法，并且可能是评估早期皮肤对辐射反应的一种有临床意义的方法。
