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软骨与颞肌筋膜移植的Ⅰ型鼓室成形术效果:一项长期回顾性研究

Type 1 Tympanoplasty Outcomes between Cartilage and Temporal Fascia Grafts: A Long-Term Retrospective Study.

作者信息

Ferlito Salvatore, Fadda Gianluca, Lechien Jerome Rene, Cammaroto Giovanni, Bartel Ricardo, Borello Andrea, Cavallo Giovanni, Piccinini Francesca, La Mantia Ignazio, Cocuzza Salvatore, Merlino Federico, Achena Andrea, Brucale Cristina, Mat Quentin, Gargula Stéphane, Fakhry Nicolas, Maniaci Antonino

机构信息

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia" ENT Section, University of Catania, 95123 Catania, Italy.

Department of Otorhinolaryngology, San Luigi Gonzaga University Hospital, Universita degli Studi di Torino, 10121 Turin, Italy.

出版信息

J Clin Med. 2022 Nov 26;11(23):7000. doi: 10.3390/jcm11237000.

Abstract

Background: To compare the functional and anatomical results of two different types of grafts in type 1 tympanoplasty (TPL I). Methods: A retrospective comparative bicentric study was conducted on patients treated with TPL I using temporal fascia or tragal cartilage. We evaluated the functional and anatomical results with intergroup and intragroup analyses. Variables predicting long-term success were also evaluated. Results: A total of 142 patients (98 fascia graft vs. 44 cartilage) were initially assessed, with a mean follow-up of 67.1 ± 3.2 months. No significant differences were observed between the two groups on the intergroup analysis of age, gender, ear side, or pre-operative hearing data (all p > 0.05). At the intragroup analysis of auditory outcomes, both groups demonstrated a significant improvement in post-operative air conduction, with greater gain for the fascia group at 6 months follow-up (p < 0.001 for both); however, at long-term follow-up, cartilage demonstrated better stability results (p < 0.001). When comparing the pre-and post-operative air-bone-gap (ABG), both groups showed a significant gain (p < 0.001); the fascia group showed that at 6 months, a greater ABG increase was found, but the difference was not statistically significant (4.9 ± 0.9 dB vs. 5.3 ± 1.2 dB; p = 0.04). On the contrary, the cartilage group at long-term follow-up at 5 years maintained greater outcomes (10 ± 1.6 dB vs. 6.4 ± 2 dB; p < 0.001). Lower age (F = 4.591; p = 0.036) and higher size of perforation (F = 4.820; p = 0.030) were predictors of long-term functional success. Conclusions: The graft material selection should consider several factors influencing the surgical outcome. At long-term follow-up, the use of a cartilage graft could result in more stable audiological outcomes, especially in younger patients or in case of wider perforations.

摘要

背景

比较两种不同类型移植物在Ⅰ型鼓室成形术(TPL I)中的功能和解剖学结果。方法:对采用颞肌筋膜或耳屏软骨进行TPL I治疗的患者进行回顾性双中心比较研究。我们通过组间和组内分析评估功能和解剖学结果。还评估了预测长期成功的变量。结果:最初评估了142例患者(98例使用筋膜移植物,44例使用软骨移植物),平均随访67.1±3.2个月。在年龄、性别、患耳侧别或术前听力数据的组间分析中,两组之间未观察到显著差异(所有p>0.05)。在听觉结果的组内分析中,两组术后气导均有显著改善,筋膜组在6个月随访时改善更大(两者p<0.001);然而,在长期随访中,软骨显示出更好的稳定性结果(p<0.001)。比较术前和术后气骨导差(ABG)时,两组均有显著改善(p<0.001);筋膜组在6个月时ABG增加更大,但差异无统计学意义(4.9±0.9dB对5.3±1.2dB;p=0.04)。相反,软骨组在5年的长期随访中保持了更好的结果(10±1.6dB对6.4±2dB;p<0.001)。年龄较小(F=4.591;p=0.036)和穿孔面积较大(F=4.820;p=0.030)是长期功能成功的预测因素。结论:移植物材料的选择应考虑影响手术结果的几个因素。在长期随访中,使用软骨移植物可能会导致更稳定的听力学结果,尤其是在年轻患者或穿孔较大的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acf9/9740685/ffc01ad0ac93/jcm-11-07000-g001.jpg

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