Guziejko Katarzyna, Moniuszko-Malinowska Anna, Czupryna Piotr, Dubatówka Marlena, Łapińska Magda, Raczkowski Andrzej, Sowa Paweł, Kiszkiel Łukasz, Minarowski Łukasz, Moniuszko Marcin, Groth Monika, Kaminski Karol A
2nd Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Zurawia 14, 15-540 Bialystok, Poland.
Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Zurawia 14, 15-540 Bialystok, Poland.
J Clin Med. 2022 Nov 29;11(23):7052. doi: 10.3390/jcm11237052.
Background: The aim of the study was to investigate the impact of COVID-19 on the pulmonary function tests (PFT) in COVID-19 convalescents six months after recovery. Additionally, the research question was whether PFT should be performed routinely in post-COVID-19 patients. Methods: A total of 39 patients with a history of COVID-19 6 months prior to the study were included in the study (Group I). Individuals were hospitalized or treated in the outpatients department. The control group (Group II) consisted of 39 healthy patients without a COVID-19 history. Each subject completed a questionnaire interview and underwent laboratory and pulmonary function examinations. Results: Six months after COVID-19 recovery, patients mainly complained about cough (46%, n = 18), shortness of breath (23%, n = 9), weakness (13%, n = 5), and memory/concentration disorders (8%, n = 3). In the group of patients complaining of persistent cough present 6 months after COVID-19, the following PFT parameters were decreased: FEV1, FVC, FRC, TLC, and DLCO (p < 0.05) in comparison with patients without this symptom. Conclusions: Persistent shortness of breath is not necessarily associated with pulmonary function impairment in patients 6 months after SARS-CoV-2 infection, and hence it requires appropriate differential diagnosis. Patients with a cough persisting 6 months after the acute phase of COVID-19 may benefit from PFT.
本研究的目的是调查新冠病毒感染康复六个月后，新冠病毒病（COVID-19）对康复者肺功能测试（PFT）的影响。此外，研究问题是COVID-19康复后的患者是否应常规进行肺功能测试。方法：本研究纳入了39例在研究前6个月有COVID-19病史的患者（第一组）。这些个体曾住院治疗或在门诊接受治疗。对照组（第二组）由39例无COVID-19病史的健康患者组成。每位受试者均完成了问卷调查，并接受了实验室检查和肺功能检查。结果：COVID-19康复六个月后，患者主要抱怨咳嗽（46%，n = 18）、气短（23%，n = 9）、乏力（13%，n = 5）以及记忆/注意力障碍（8%，n = 3）。在COVID-19六个月后仍有持续性咳嗽的患者组中，与无此症状的患者相比，以下肺功能测试参数降低：第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、功能残气量（FRC）、肺总量（TLC）和一氧化碳弥散量（DLCO）（p < 0.05）。结论：SARS-CoV-2感染六个月后的患者，持续性气短不一定与肺功能损害相关，因此需要进行适当的鉴别诊断。COVID-19急性期六个月后仍有咳嗽的患者可能会从肺功能测试中受益。
