Crimì Alberto, Binitie Odion T, Crimì Filippo, Letson G Douglas, Joyce David M
Department of Orthopedics and Orthopedic Oncology, University of Padova, 35128 Padua, Italy.
Sarcoma Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
J Clin Med. 2022 Nov 30;11(23):7111. doi: 10.3390/jcm11237111.
(1) Background: Pelvic Chondrosarcomas (CS) have a poor prognosis. The grade is the most important survival predictor; other factors are periacetabular location and Dedifferentiated CS subtype. The aim of the study is to investigate a series of CS of the pelvis, to analyze the prognostic factors that affect outcomes and to demonstrate how the use of intraoperative navigation can reduce the complications without worse outcomes. (2) Methods: Retrospective study on 35 patients (21 M, 14 F), median age at surgery 54 years (IQR 41−65), with pelvic CS, treated with hemipelvectomy under navigation guidance. (3) Results: 30 high-grade CS and 5 low-grade CS; mean follow-up 51.4 months. There was a positive linear correlation between the tumor volume and the presence of local recurrence at follow-up. The mean survival time of patients with larger chondrosarcoma volume was lower, but not significantly so. Lower MSTS score was associated with significantly lower survival time (p < 0.001). (4) Conclusion: in this series overall survival, LR and distant metastasis were comparable with recent literature, while complication rate was lower compared to similar series without the use of navigation. There was a correlation between tumor volume and local recurrence rate but not with the presence of metastasis at follow up.
(1) 背景:盆腔软骨肉瘤(CS)预后较差。分级是最重要的生存预测指标;其他因素为髋臼周围位置和去分化CS亚型。本研究的目的是调查一系列盆腔CS病例,分析影响预后的因素,并证明术中导航的使用如何减少并发症且不影响预后。(2) 方法:对35例患者(21例男性,14例女性)进行回顾性研究,手术时的中位年龄为54岁(四分位间距41 - 65岁),患有盆腔CS,在导航引导下接受半骨盆切除术治疗。(3) 结果:30例高级别CS和5例低级别CS;平均随访51.4个月。随访时肿瘤体积与局部复发的存在之间存在正线性相关性。软骨肉瘤体积较大的患者平均生存时间较低,但差异无统计学意义。较低的肌肉骨骼肿瘤学会(MSTS)评分与显著较低的生存时间相关(p < 0.001)。(4) 结论:在本系列中,总体生存率、局部复发率和远处转移率与近期文献相当,而与未使用导航的类似系列相比,并发症发生率较低。肿瘤体积与局部复发率之间存在相关性,但与随访时转移的存在无关。