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磷霉素治疗导管相关性尿路感染有效性的尿液检测与培养的比较研究

A Comparative Study of Urinary Tests and Cultures for the Effectiveness of Fosfomycin in Catheter-Related Urinary Tract Infections.

作者信息

Jo Jung Ki, Kim Dong Seob, Sim Younghun, Ryu Soorack, Kim Kyu Shik

机构信息

Department of Urology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea.

Biostatistical Consulting and Research Laboratory, Medical Research Collaborating Center, Hanyang University, Seoul 04763, Republic of Korea.

出版信息

J Clin Med. 2022 Dec 5;11(23):7229. doi: 10.3390/jcm11237229.

Abstract

As the elderly population increases due to an aging society, the number of patients with catheters is increasing, and treatment for urinary infections is needed. The current study analyzed the effectiveness of fosfomycin, the primary antibiotic used to treat urinary tract infections (UTIs), in these patients. Patients who received fosfomycin as the primary antibiotic for a UTI were selected, and the results of urine tests and cultures before and after fosfomycin administration were compared and analyzed. The degree of UTI in patients with a catheter was found to be more severe ( = 0.020), and the infecting strains were found to be different depending on whether a catheter was present ( = 0.014). There was a difference in the treatment success rate depending on whether or not a catheter was present (53.6% vs. 70.4%), but it was found that the treatment rate was more than 50% regardless of whether a catheter was present. The bacterial type, as well as the treatment rate based on the bacterium, differed depending on the presence of a catheter. Fosfomycin has a success rate of more than 50%, even in patients with catheters; therefore, it can be considered the primary antibiotic for treating UTIs.

摘要

随着社会老龄化导致老年人口增加,导尿管患者数量不断上升,因此需要对尿路感染进行治疗。本研究分析了用于治疗尿路感染(UTIs)的主要抗生素磷霉素对这些患者的疗效。选取以磷霉素作为尿路感染主要抗生素的患者,比较并分析了磷霉素给药前后的尿液检查和培养结果。发现有导尿管患者的尿路感染程度更严重( = 0.020),并且根据是否有导尿管,感染菌株有所不同( = 0.014)。有无导尿管的治疗成功率存在差异(53.6%对70.4%),但发现无论有无导尿管,治疗率均超过50%。细菌类型以及基于细菌的治疗率因有无导尿管而有所不同。即使在有导尿管的患者中,磷霉素的成功率也超过50%;因此,它可被视为治疗尿路感染的主要抗生素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b2/9736013/e83f172b18fb/jcm-11-07229-g001.jpg

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