Ono Shoma, Mizushiri Satoru, Nishiya Yuki, Tamura Ayumi, Hamaura Kiho, Ito Ryoma, Terada Akihide, Tanabe Jutaro, Yanagimachi Miyuki, Wai Kyi Mar, Sawada Kaori, Ihara Kazushige, Daimon Makoto
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki 036-8216, Aomori, Japan.
Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki 036-8216, Aomori, Japan.
J Clin Med. 2022 Dec 5;11(23):7232. doi: 10.3390/jcm11237232.
The relationship between serum adiponectin concentration (S-Adipo) and various diseases, such as type 2 diabetes (T2D) is conflicting. We hypothesized that the extent of kidney damage in patients with T2D may be responsible for this inconsistency and, thus, examined association between S-Adipo and T2D after consideration for the extent of kidney damage present. Of the 1816 participants in the population-based Iwaki study of Japanese people, 1751 participants with a complete dataset were included. Multivariate logistic regression analyses revealed that low S-Adipo was independently associated with T2D (<0.001), as was high urinary albumin to creatinine ratio (uACR) (<0.001). Principal components analysis showed that the relative value of S-Adipo to uACR (adiponectin relative excess) was significantly associated with T2D (odds ratio: 0.49, p < 0.001). Receiver operating curve analyses revealed that an index of adiponectin relative excess the ratio of S-Adipo to uACR was superior to S-Adipo per se as a marker of T2D (area under the curve: 0.746 vs. 0.579, p < 0.001). This finding indicates that the relationship between S-Adipo and T2D should be evaluated according to the extent of kidney damage present and may warrant similar analyses of the relationships between S-Adipo and other medicalconditions, such as cardiovascular disease.
血清脂联素浓度（S-Adipo）与2型糖尿病（T2D）等各种疾病之间的关系存在矛盾。我们推测，T2D患者的肾脏损伤程度可能是造成这种不一致的原因，因此，在考虑了现有肾脏损伤程度后，研究了S-Adipo与T2D之间的关联。在基于人群的岩城日本人研究的1816名参与者中，纳入了1751名拥有完整数据集的参与者。多变量逻辑回归分析显示，低S-Adipo与T2D独立相关（<0.001），高尿白蛋白肌酐比值（uACR）也是如此（<0.001）。主成分分析表明，S-Adipo与uACR的相对值（脂联素相对过量）与T2D显著相关（比值比：0.49，p<0.001）。受试者工作特征曲线分析显示，脂联素相对过量指数（S-Adipo与uACR的比值）作为T2D的标志物优于S-Adipo本身（曲线下面积：0.746对0.579，p<0.001）。这一发现表明，S-Adipo与T2D之间的关系应根据现有肾脏损伤程度进行评估，并且可能需要对S-Adipo与其他疾病（如心血管疾病）之间的关系进行类似分析。
