Rastegari Kimiya, Mokhtari-Dizaji Manijhe, Harirchian Mohammad Hossein, Hashemi Hassan, Ayoobi Yazdi Niloofar, Saberi Hazhir
Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Iranian Center of Neurological Research, Imam Khomeini Hospital, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Ultrasonography. 2023 Jan;42(1):100-110. doi: 10.14366/usg.22053. Epub 2022 Aug 23.
Investigations of the hemodynamic changes of the venous system in patients with multiple sclerosis (MS) have shown contradictory results. Herein, the biomechanical parameters of the internal jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals.
B-mode and Doppler sequential ultrasound images of 64 IJVs and CCAs of women including 22 healthy individuals, 22 relapsing-remitting multiple sclerosis (RRMS) patients, and 20 primary-progressive multiple sclerosis (PPMS) patients were recorded and processed. The biomechanical parameters of the IJV and the CCA walls during three cardiac cycles were calculated.
The IJV maximum and minimum pressures were higher in the MS patients than in the healthy subjects, by 31% and 19% in RRMS patients and 39% and 24% in PPMS patients. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher than in healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients was 70% and 75% lower, and compliance was 40% and 59% lower than in healthy subjects. The maximum intima-media thicknesses of the CCAs were 38% and 24%, and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients than in healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients was 17% and 31%, and the radial elastic moduli were 47% and 9% higher than in healthy individuals.
Some physical and biomechanical parameters of the CCA and IJV showed significant differences between MS patients and healthy individuals.
对多发性硬化症（MS）患者静脉系统血流动力学变化的研究结果相互矛盾。在此，提取了MS患者颈内静脉（IJV）和颈总动脉（CCA）的生物力学参数，并与健康个体进行比较。
记录并处理了包括22名健康个体、22名复发缓解型多发性硬化症（RRMS）患者和20名原发进展型多发性硬化症（PPMS）患者在内的64条IJV和CCA的B超和多普勒序列超声图像。计算了三个心动周期内IJV和CCA血管壁的生物力学参数。
MS患者的IJV最大和最小压力高于健康受试者，RRMS患者分别高31%和19%，PPMS患者分别高39%和24%。RRMS和PPMS患者的静脉壁厚度分别比健康受试者高51%和60%。RRMS和PPMS患者的IJV扩张性分别比健康受试者低70%和75%，顺应性分别低40%和59%。RRMS和PPMS患者CCA的最大内膜中层厚度分别比健康个体高38%和24%，最小内膜中层厚度分别高27%和23%。RRMS和PPMS患者CCA血管壁的剪切模量分别比健康个体高17%和31%，径向弹性模量分别高47%和9%。
MS患者与健康个体之间，CCA和IJV的一些物理和生物力学参数存在显著差异。
