Department of Patient Safety Unit/Anesthesia, Kyoto University Hospital, Kyoto, Japan.
Medical Affairs Division, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Expert Opin Pharmacother. 2023 Feb;24(2):267-282. doi: 10.1080/14656566.2022.2155048. Epub 2022 Dec 15.
Mirogabalin has been attracting attention for treating peripheral neuropathic pain. The package insert recommends that mirogabalin should be titrated depending on renal function. Here, we investigated the relationship between dose titration patterns and adherence, and persistence of mirogabalin treatment.
Peripheral neuropathic pain patients who initiated mirogabalin between March 2020 and May 2021 were identified using an electronic medical record database. The dose titration pattern was described according to degrees of renal function. Regression analyses were performed to compare adherence and persistence between the patients with and without titration.
Of the 4,138 identified patients, 1,696 (41.0%) titrated the dose within 45 days and were more adherent than those without titration (Adjusted odds ratio: 1.75, 95% CI 1.21, 2.54). Of the total 952 patients with renal function parameters, 229 (24.1%) titrated to the effective dose within 45 days and were less likely to discontinue than those without titration (Adjusted hazard ratio: 0.57, 95% CI 0.40, 0.81).
Mirogabalin dose titration was associated with better adherence and persistence. It is important for mirogabalin treatment to determine the initial prescription dose based on renal function and subsequent dose titration according to the package insert.
UMIN000047313.
米罗 gabalin 因其治疗周围神经性疼痛而受到关注。说明书建议根据肾功能调整米罗 gabalin 的剂量。在此，我们研究了剂量调整模式与米罗 gabalin 治疗的依从性和持续性之间的关系。
使用电子病历数据库，确定了 2020 年 3 月至 2021 年 5 月期间开始使用米罗 gabalin 的周围神经性疼痛患者。根据肾功能程度描述剂量调整模式。回归分析比较了剂量调整和未调整患者的依从性和持续性。
在确定的 4138 名患者中，有 1696 名（41.0%）在 45 天内调整了剂量，比未调整剂量的患者更具依从性（调整后的优势比：1.75，95%可信区间 1.21，2.54）。在有肾功能参数的 952 名患者中，有 229 名（24.1%）在 45 天内调整至有效剂量，比未调整剂量的患者更不容易停药（调整后的危险比：0.57，95%可信区间 0.40，0.81）。
米罗 gabalin 剂量调整与更好的依从性和持续性相关。根据肾功能确定初始处方剂量，并根据说明书进行后续剂量调整，对于米罗 gabalin 治疗非常重要。
UMIN000047313。
