Molina-Ortiz Dora, Torres-Zárate Carmen, Santes-Palacios Rebeca
Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Coyoacán 04530, Mexico City, México.
Curr Drug Metab. 2022;23(12):942-963. doi: 10.2174/1389200224666221209153032.
Orphan cytochromes P450 (CYP) are enzymes whose biological functions and substrates are unknown. However, the use of new experimental strategies has allowed obtaining more information about their relevance in the metabolism of endogenous and exogenous compounds. Likewise, the modulation of their expression and activity has been associated with pathogenesis and prognosis in different diseases. In this work, we review the regulatory pathways and the possible role of orphan CYP to provide evidence that allow us to stop considering some of them as orphan enzymes and to propose them as possible therapeutic targets in the design of new strategies for the treatment of diseases associated with CYP-mediated metabolism.
孤儿细胞色素P450（CYP）是一类生物学功能和底物未知的酶。然而，新实验策略的应用使得人们能够获取更多关于它们在内外源化合物代谢中相关性的信息。同样，它们的表达和活性调节与不同疾病的发病机制和预后相关。在这项工作中，我们综述了孤儿CYP的调控途径及其可能的作用，以提供证据，使我们不再将其中一些酶视为孤儿酶，并提议将它们作为设计与CYP介导的代谢相关疾病治疗新策略时可能的治疗靶点。
