Departamento de Medicina Interna, Dermatología y Psiquiatría, Facultad de Ciencias de la Salud, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain.
Consultoría Psiquiátrica SC, Santa Cruz de Tenerife, Spain.
Acta Neuropsychiatr. 2023 Jun;35(3):138-146. doi: 10.1017/neu.2022.37. Epub 2022 Dec 12.
The s100b inflammatory protein is involved in schizophrenia pathophysiology. We aim at studying the evolution of the s100b serum levels in acutely relapsed paranoid schizophrenia patients at three different time points (admission, discharge and 3 months after hospital discharge 3MAHD).
Twenty-three paranoid schizophrenia inpatients meeting DSM-IV criteria participated in the research. Twenty-three healthy subjects matched by age, gender and season acted as the control group. Psychopathology was measured with the Positive and Negative Syndrome Scale (PANSS). Serum s100b levels were determined at 12:00 and 24:00 h with an enzyme-linked immunoassay kit.
Patients had significant higher serum s100b levels at admission and discharge (12:00 h) than the group of healthy subjects. At admission and discharge, s100b serum levels at 24 h had decreased compared to the 24:00 h s100b levels of the healthy subjects. At 3MAHD patients and healthy subjects had similar levels of serum s100b protein. Positive and negative PANSS scores decreased significantly between admission and discharge. Positive and negative PANSS scores decreased between discharge and 3MAHD, but these changes had no statistical significance.
Our study confirms that the acute inflammatory response produced in acutely relapsed patients is reversed after 3 month of hospital discharge. The variations of serum s100b concentrations when the patients suffer from an acute relapse may be a useful predictor of disease evolution.
S100B 炎症蛋白与精神分裂症的病理生理学有关。我们旨在研究三种不同时间点（入院时、出院时和出院后 3 个月）急性复发偏执型精神分裂症患者的 S100B 血清水平变化。
23 名符合 DSM-IV 标准的住院偏执型精神分裂症患者参与了这项研究。23 名年龄、性别和季节相匹配的健康受试者作为对照组。采用阳性和阴性综合征量表（PANSS）评估精神病理学。在 12:00 和 24:00 时使用酶联免疫试剂盒测定血清 S100B 水平。
患者入院时和出院时（12:00 h）的血清 S100B 水平明显高于健康对照组。入院时和出院时，与健康对照组 24:00 h 的 S100B 水平相比，24 h 的 S100B 血清水平有所下降。在 3MAHD 时，患者和健康对照组的血清 S100B 蛋白水平相似。入院时和出院时，阳性和阴性 PANSS 评分显著降低。出院时和 3MAHD 时，阳性和阴性 PANSS 评分下降，但这些变化无统计学意义。
本研究证实，急性复发患者体内产生的急性炎症反应在出院后 3 个月得到逆转。急性复发患者血清 S100B 浓度的变化可能是疾病演变的一个有用预测指标。
