Kozlowski Tomasz, Bargiel Weronika, Grabarczyk Maksymilian, Skibinska Maria
Student's Research Group "Biology of the Neuron", Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
Protein Biomarkers Unit, Department of Psychiatric Genetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
Brain Sci. 2023 Sep 16;13(9):1334. doi: 10.3390/brainsci13091334.
Five major psychiatric disorders: schizophrenia, major depressive disorder, bipolar disorder, autistic spectrum disorder, and attention-deficit/hyperactivity disorder, show a shared genetic background and probably share common pathobiological mechanisms. S100B is a calcium-binding protein widely studied in psychiatric disorders as a potential biomarker. Our systematic review aimed to compare studies on peripheral S100B levels in five major psychiatric disorders with shared genetic backgrounds to reveal whether S100B alterations are disease-specific. EMBASE, Web of Science, and PubMed databases were searched for relevant studies published until the end of July 2023. This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA) guidelines. Overall, 1215 publications were identified, of which 111 full-text articles were included in the systematic review. Study designs are very heterogeneous, performed mostly on small groups of participants at different stages of the disease (first-episode or chronic, drug-free or medicated, in the exacerbation of symptoms or in remission), and various clinical variables are analyzed. Published results are inconsistent; most reported elevated S100B levels across disorders included in the review. Alterations in S100B peripheral levels do not seem to be disease-specific.
精神分裂症、重度抑郁症、双相情感障碍、自闭症谱系障碍和注意力缺陷多动障碍，显示出共同的遗传背景，并且可能共享常见的病理生物学机制。S100B是一种钙结合蛋白，作为一种潜在的生物标志物，在精神疾病中得到了广泛研究。我们的系统评价旨在比较关于具有共同遗传背景的五种主要精神疾病外周血S100B水平的研究，以揭示S100B的改变是否具有疾病特异性。检索了EMBASE、科学网和PubMed数据库中截至2023年7月底发表的相关研究。本研究按照系统评价和Meta分析方案优先报告条目（PRISMA）指南进行。总体而言，共识别出1215篇出版物，其中111篇全文文章纳入了系统评价。研究设计非常异质性，大多在疾病不同阶段（首发或慢性、未用药或用药、症状加重期或缓解期）的小样本参与者中进行，并且分析了各种临床变量。已发表的结果不一致；大多数报告显示，纳入评价的所有疾病的S100B水平均升高。S100B外周水平的改变似乎不具有疾病特异性。
