Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Curr Opin Allergy Clin Immunol. 2023 Feb 1;23(1):44-50. doi: 10.1097/ACI.0000000000000870. Epub 2022 Dec 8.
Asthma exacerbations are major factors in asthma morbidity and also have long-term consequences.
Asthma is characterized by an accelerated and progressive loss of lung function. Recent evidence has pointed to the frequency of exacerbations as being a significant contributor to a loss of lung function in asthma.
A consequence of asthma exacerbations is a greater loss of lung function. Airway inflammation is central to asthma severity and susceptibility for exacerbations. Evidence suggests that the increase in airway inflammation during an asthma exacerbation further compromised lung function. Treatment of severe asthma with Type (T)-2 directed biologics significantly prevents the frequency of exacerbations in severe asthma. Early indications also suggest that prevention of exacerbations by biologics may reduce a loss in lung function from exacerbations.
哮喘加重是哮喘发病率的主要因素，也有长期后果。
哮喘的特征是肺功能加速和逐渐丧失。最近的证据表明，加重的频率是哮喘患者肺功能丧失的一个重要因素。
哮喘加重的后果是肺功能更大程度的丧失。气道炎症是哮喘严重程度和易发性加重的核心。有证据表明，哮喘加重期间气道炎症的增加进一步损害了肺功能。使用 2 型靶向生物制剂治疗严重哮喘可显著降低严重哮喘的加重频率。早期迹象还表明，生物制剂预防加重可能会减少因加重而导致的肺功能丧失。
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