Engdahl Karolina, Boge Gudrun Seeberg, Ingman Jessica, Näslund Veronica, Ley Charles J
Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences-School of Veterinary Science, Oslo, Norway.
Vet Rec. 2023 Apr;192(7):e2478. doi: 10.1002/vetr.2478. Epub 2022 Dec 11.
Concurrent osteoarthritis is generally present in the stifle joints of dogs with cranial cruciate ligament disease (CCLD), but it is not known if the degree of osteoarthritis-related changes affects the prognosis. Development of osteophytes is a key radiographic feature of osteoarthritis. The aim of this study was to evaluate the association between the degree of osteophyte formation seen on radiographs and CCLD-related euthanasia in dogs with CCLD.
A retrospective cohort study including 226 dogs treated for CCLD at two university animal hospitals was performed. Clinical and follow-up information was retrieved, and stifle radiographs taken during the 31 days before treatment for the CCLD were graded for osteophyte formation by three veterinary radiologists. A multivariable Cox proportional hazards model was applied to assess the association between the degree of osteophyte formation and CCLD-related euthanasia.
An association between the degree of osteophyte formation and CCLD-related euthanasia was found, with increased osteophyte formation associated with an increased hazard of CCLD-related euthanasia (hazard ratio 1.06, 95% confidence interval 1.01-1.11, p = 0.01).
No clinical assessment of the outcome was performed.
The findings suggest that evaluation of stifle radiographs for osteophyte formation could provide useful prognostic information for dogs with CCLD.
并发骨关节炎通常存在于患有前十字韧带疾病（CCLD）的犬的膝关节中，但尚不清楚骨关节炎相关变化的程度是否会影响预后。骨赘形成是骨关节炎的关键影像学特征。本研究的目的是评估在患有CCLD的犬中，X线片上可见的骨赘形成程度与CCLD相关的安乐死之间的关联。
进行了一项回顾性队列研究，纳入了在两家大学动物医院接受CCLD治疗的226只犬。检索临床和随访信息，并由三名兽医放射科医生对CCLD治疗前31天内拍摄的膝关节X线片进行骨赘形成分级。应用多变量Cox比例风险模型评估骨赘形成程度与CCLD相关安乐死之间的关联。
发现骨赘形成程度与CCLD相关安乐死之间存在关联，骨赘形成增加与CCLD相关安乐死的风险增加相关（风险比1.06，95%置信区间1.01-1.11，p = 0.01）。
未对结果进行临床评估。
研究结果表明，评估膝关节X线片上的骨赘形成可为患有CCLD的犬提供有用的预后信息。
