咖啡因、茶碱和氨茶碱对电休克治疗的影响：证据综述
Effects of Caffeine, Theophylline, and Aminophylline on Electroconvulsive Therapy: A Review of Evidence.
作者信息
Althagafi Abdulhamid
机构信息
Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
J Microsc Ultrastruct. 2021 Aug 6;10(3):103-106. doi: 10.4103/jmau.jmau_19_21. eCollection 2022 Jul-Sep.
BACKGROUND
Electroconvulsive therapy (ECT) is a highly efficacious treatment modality used to produce seizures in patients diagnosed with major depressive disorders and psychotic episodes. In general, ECT treatment is successful in most patients; however, in some populations, ECT fails to produce adequate response. Caffeine, theophylline, and aminophylline are documented to augment seizure activity in ECT. By inhibiting adenosine, these medications can improve ECT response rate in a certain patient population. Caffeine and aminophylline have been documented to prolong seizure duration. Theophylline has been shown to improve seizure duration along with decreasing seizure threshold. All of these medications have very minimal side effect profiles. This review will discuss up-to-date evidence on the effects of xanthine derivatives in patients receiving ECT treatment.
METHODS
A literature review of PubMed and EMBASE was performed for related studies.
RESULTS
Eight studies were included in our review. Premedication with caffeine, theophylline, or aminophylline was associated with increased seizure duration in patients suffering from mental disorders and were indicated to manage ECT.
CONCLUSION
Xanthine derivatives prolong seizure duration in patients treated with ECT.
背景
电休克疗法（ECT）是一种用于在被诊断患有重度抑郁症和精神病发作的患者中引发癫痫发作的高效治疗方式。一般而言，ECT治疗在大多数患者中是成功的；然而，在某些人群中，ECT未能产生足够的反应。据记载，咖啡因、茶碱和氨茶碱可增强ECT中的癫痫活动。通过抑制腺苷，这些药物可提高特定患者群体的ECT反应率。据记载，咖啡因和氨茶碱可延长癫痫发作持续时间。已表明茶碱可改善癫痫发作持续时间并降低癫痫发作阈值。所有这些药物的副作用都非常小。本综述将讨论关于黄嘌呤衍生物对接受ECT治疗患者影响的最新证据。
方法
对PubMed和EMBASE进行文献检索以查找相关研究。
结果
我们的综述纳入了八项研究。在患有精神障碍的患者中，术前使用咖啡因、茶碱或氨茶碱与癫痫发作持续时间延长相关，并且被表明可用于ECT治疗。
结论
黄嘌呤衍生物可延长接受ECT治疗患者的癫痫发作持续时间。
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