Cortés-Penfield Nicolás W, Hewlett Angela L, Kalil Andre C
Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Open Forum Infect Dis. 2022 Oct 31;9(12):ofac582. doi: 10.1093/ofid/ofac582. eCollection 2022 Dec.
Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43-5.02), but no greater cure with other rifampin combinations vs regimens without rifampin (OR, 1.22; 95% CI, 0.79-1.88).
利福平对保留的葡萄球菌人工关节感染是否有益尚无定论。在一项对8项研究的荟萃分析中，我们发现氟喹诺酮-利福平联合用药组的临床治愈率高于所有其他治疗方案（优势比[OR]，2.68；95%置信区间[CI]，1.43 - 5.02），但利福平与其他药物联合使用的方案与不含利福平的方案相比，治愈率并无更高（OR，1.22；95% CI，0.79 - 1.88）。
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