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清创及植入物保留术后利福平辅助治疗金黄色葡萄球菌人工关节感染：若不联合氟喹诺酮类药物是否有效？

Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?

作者信息

Cortés-Penfield Nicolás W, Hewlett Angela L, Kalil Andre C

机构信息

Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

出版信息

Open Forum Infect Dis. 2022 Oct 31;9(12):ofac582. doi: 10.1093/ofid/ofac582. eCollection 2022 Dec.

DOI:10.1093/ofid/ofac582
PMID:36504699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9728514/
Abstract

Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43-5.02), but no greater cure with other rifampin combinations vs regimens without rifampin (OR, 1.22; 95% CI, 0.79-1.88).

摘要

利福平对保留的葡萄球菌人工关节感染是否有益尚无定论。在一项对8项研究的荟萃分析中，我们发现氟喹诺酮-利福平联合用药组的临床治愈率高于所有其他治疗方案（优势比[OR]，2.68；95%置信区间[CI]，1.43 - 5.02），但利福平与其他药物联合使用的方案与不含利福平的方案相比，治愈率并无更高（OR，1.22；95% CI，0.79 - 1.88）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f43c/9728514/f846c5dc4416/ofac582f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f43c/9728514/f846c5dc4416/ofac582f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f43c/9728514/f846c5dc4416/ofac582f1.jpg

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2
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3
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