Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, Kitasato University School of Pharmacy, Shirokane, Japan.
Department of Pharmacy, Kitasato University Medical Center, Kitamoto, Japan.
Front Public Health. 2022 Nov 22;10:985494. doi: 10.3389/fpubh.2022.985494. eCollection 2022.
We aimed to clarify the relationship between coronavirus disease 2019 (COVID-19) reinfection and basic disease and smoking status.
The electronic health records of 165,320 patients with COVID-19 from January 1, 2020, to August 27, 2021, were analyzed. Data on age, race, sex, smoking status (never, current, former), and basic disease were analyzed using Cox proportional hazard models.
In total, 6,133 patients (3.7%) were reinfected. The overall reinfection rate for never, current, and former smokers was 4.2, 3.5, and 5.7%, respectively. Although the risk of reinfection was highest among former smokers aged ≥65 years (7.7% [422/5,460]), the reinfection rate among current smokers aged ≥65 years was 6.2% (341/5,543). Among reinfected patients, the number of basic diseases was higher in former smokers (2.41 ± 1.16) than in current (2.28 ± 1.07, = 0.07) and never smokers (2.07 ± 1.05, < 0.001). Former smokers who are older may have been exposed to factors that increase their risk of symptomatic COVID-19 reinfection.
我们旨在阐明 2019 年冠状病毒病（COVID-19）再感染与基础疾病和吸烟状况之间的关系。
分析了 2020 年 1 月 1 日至 2021 年 8 月 27 日期间 165320 例 COVID-19 患者的电子健康记录。使用 Cox 比例风险模型分析年龄、种族、性别、吸烟状况（从不、现在、曾经）和基础疾病的数据。
共有 6133 例患者（3.7%）再次感染。从不吸烟、现在吸烟和曾经吸烟的患者的总体再感染率分别为 4.2%、3.5%和 5.7%。虽然≥65 岁的曾经吸烟者再感染风险最高（7.7%[422/5460]），但≥65 岁的现在吸烟者的再感染率为 6.2%（341/5543）。在再感染患者中，曾经吸烟者的基础疾病数量高于现在吸烟者（2.41±1.16）和从不吸烟者（2.07±1.05，<0.001）。年龄较大的曾经吸烟者可能接触到增加其有症状 COVID-19 再感染风险的因素。
