Division of Pulmonary and Critical Care Medicine. Department of Internal Medicine, University of Texas Medical Branch. Galveston, TX, USA.
Division of Pulmonary and Critical Care Medicine. Department of Internal Medicine, University of Texas Medical Branch. Galveston, TX, USA.
Respir Med. 2021 Jun;182:106414. doi: 10.1016/j.rmed.2021.106414. Epub 2021 Apr 17.
The association between smoking status and severe Coronavirus Disease 2019 (COVID-19) remains controversial.
To assess the risk of hospitalization (as a marker of severe COVID-19) in patients by smoking status: former, current and never smokers, who tested positive for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2) at an academic medical center in the United States.
We conducted a retrospective cohort study in patients with SARS-COV2 between March-1-2020 and January-31-2021 to identify the risk of hospitalization due to COVID-19 by smoking status.
We identified 10216 SARS-COV2-positive patients with complete documentation of smoking habits. Within 14 days of a SARS-COV2 positive test, 1150 (11.2%) patients were admitted and 188 (1.8%) died. Significantly more former smokers were hospitalized from COVID-19 than current or never smokers (21.2% former smokers; 7.3% current smokers; 10.4% never smokers, p<0.0001). In univariable analysis, former smokers had higher odds of hospitalization from COVID-19 than never smokers (OR 2.31; 95% CI 1.94-2.74). This association remained significant when analysis was adjusted for age, race and gender (OR 1.28; 95% CI 1.06-1.55), but became non-significant when analysis included Body Mass Index, previous hospitalization and number of comorbidities (OR 1.05; 95% CI 0.86-1.29). In contrast, current smokers were less likely than never smokers to be hospitalized due to COVID-19.
Significantly more former smokers were hospitalized and died from COVID-19 than current or never smokers. This effect is mediated via age and comorbidities in former smokers.
吸烟状况与严重的 2019 年冠状病毒病（COVID-19）之间的关联仍存在争议。
评估吸烟状况（以前、现在和从不吸烟者）与因 SARS-CoV-2 感染而住院（作为 COVID-19 严重程度的标志物）的患者的住院风险：在美国的一家学术医疗中心。
我们对 2020 年 3 月 1 日至 2021 年 1 月 31 日期间的 SARS-CoV-2 阳性患者进行了回顾性队列研究，以确定吸烟状况与 COVID-19 相关的住院风险。
我们确定了 10216 例 SARS-CoV-2 阳性患者，他们的吸烟习惯有完整的记录。在 SARS-CoV-2 阳性检测后的 14 天内，有 1150 例（11.2%）患者住院，188 例（1.8%）死亡。与从不吸烟者相比，以前吸烟者因 COVID-19 住院的比例明显更高（21.2%的以前吸烟者；7.3%的当前吸烟者；10.4%的从不吸烟者，p<0.0001）。在单变量分析中，与从不吸烟者相比，以前吸烟者因 COVID-19 住院的可能性更高（OR 2.31；95%CI 1.94-2.74）。当分析调整年龄、种族和性别时，这种关联仍然显著（OR 1.28；95%CI 1.06-1.55），但当分析包括体重指数、以前的住院治疗和合并症的数量时，这种关联变得不显著（OR 1.05；95%CI 0.86-1.29）。相比之下，当前吸烟者因 COVID-19 住院的可能性小于从不吸烟者。
与当前或从不吸烟者相比，以前吸烟者因 COVID-19 住院和死亡的比例明显更高。这种影响是通过以前吸烟者的年龄和合并症来介导的。
