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针对患有情绪障碍的中国老年人的跨诊断团体认知行为干预的疗效:一项为期一年的随访随机临床试验。

The efficacy of a transdiagnostic group cognitive behavioral intervention for Chinese elderly with emotional disorders: A one-year follow-up randomized clinical trial.

作者信息

Yan Zijun, Meng Fanqiang, He Meiling, Li Zhanjiang

机构信息

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

出版信息

Front Psychiatry. 2022 Nov 25;13:1027994. doi: 10.3389/fpsyt.2022.1027994. eCollection 2022.

Abstract

BACKGROUND

With the global aging, geriatric emotional disorders have received more and more attention. Psychotherapy is an effective approach for alleviating the symptoms associated with emotional disorder, but the number of experienced therapists is low. Studies should be conducted to explore a low-cost and efficient treatment method. Previous findings indicate that transdiagnostic cognitive behavior therapy is an effective approach for treatment of emotional disorders. Group therapy is appropriate for the elderly as they are characterized by high levels of loneliness. In this study, we compared and explored the effects of a transdiagnostic group cognitive behavioral intervention (TD-GCBT), a transdiagnostic individual cognitive behavioral intervention (TD-CBT), and treatment as usual (TAU) on treatment of emotional disorders among the elderly.

METHOD

A total of 120 elderly patients diagnosed with emotional disorders were randomly assigned to the TD-GCBT group (40), TD-CBT group (40), and TAU group (40). Changes in symptoms were assessed using HAMD, PHQ-9, HAMA, and GAD-7 scales at baseline, post-treatment (three months), six-month and twelve-months follow-up. The efficacies of the three intervention strategies were compared using linear mixed-effects models. and simple effect analyses were conducted to determine the differences among the three groups.

RESULTS

The HAMD, PHQ-9, HAMA, and GAD-7 scores revealed a significant effect from baseline to 12 months for time ( < 0.001), group ( < 0.001) and time × group interaction ( < 0.001) in TD-GCBT group compared with the TD-CBT group and TAU group. The effect of TD-GCBT (HAMD: Cohen's (3th month, 6th month, 12th month) = 2.69, 3.98, 4.51; HAMA: Cohen's = 2.84, 4.13, 5.20) and TD-CBT (HAMD: Cohen's = 2.55, 2.87, 2.63; HAMA: Cohen's = 2.43, 2.83, 2.78) group was better relative to that of the TAU group (HAMD: Cohen's = 0.41, 1.13, 1.46; HAMA: Cohen's = 0.64, 1.22, 1.57) ( < 0.001). The scores of the TD-GCBT group showed the most significant decrease compared with the other two groups.

CONCLUSION

The findings indicate that TD-GCBT method is effective for treatment of emotional disorders among the elderly. TD-GCBT is effective for alleviating depression and anxiety symptoms up to at least nine months after treatment. The results indicate that TD-GCBT is a cost-effective and resource-effective strategy and can be used an alternative therapy for treatment of mental disorders.

CLINICAL TRIAL REGISTRATION

[https://www.chictr.org.cn], identifier [ChiCTR1900021806].

摘要

背景

随着全球老龄化,老年期情绪障碍越来越受到关注。心理治疗是缓解情绪障碍相关症状的有效方法,但经验丰富的治疗师数量较少。应开展研究以探索低成本且高效的治疗方法。先前的研究结果表明,跨诊断认知行为疗法是治疗情绪障碍的有效方法。团体治疗适合老年人,因为他们具有较高的孤独感。在本研究中,我们比较并探讨了跨诊断团体认知行为干预(TD-GCBT)、跨诊断个体认知行为干预(TD-CBT)和常规治疗(TAU)对老年情绪障碍治疗的效果。

方法

总共120名被诊断为情绪障碍的老年患者被随机分配到TD-GCBT组(40例)、TD-CBT组(40例)和TAU组(40例)。在基线、治疗后(三个月)、六个月和十二个月随访时,使用汉密尔顿抑郁量表(HAMD)、患者健康问卷-9(PHQ-9)、汉密尔顿焦虑量表(HAMA)和广泛性焦虑障碍量表(GAD-7)评估症状变化。使用线性混合效应模型比较三种干预策略的疗效,并进行简单效应分析以确定三组之间的差异。

结果

与TD-CBT组和TAU组相比,TD-GCBT组的HAMD、PHQ-9、HAMA和GAD-7评分显示从基线到12个月的时间(P<0.001)、组间(P<0.001)和时间×组间交互作用(P<0.001)有显著影响。TD-GCBT组(HAMD:Cohen's d(第3个月、第6个月、第12个月)=2.69、3.98、4.51;HAMA:Cohen's d =2.84、4.13、5.20)和TD-CBT组(HAMD:Cohen's d =2.55、2.87、2.63;HAMA:Cohen's d =2.43、2.83、2.78)的效果相对于TAU组(HAMD:Cohen's d =0.41、1.13、1.46;HAMA:Cohen's d =0.64、1.22、1.57)更好(P<0.001)。与其他两组相比,TD-GCBT组的评分下降最为显著。

结论

研究结果表明,TD-GCBT方法对治疗老年情绪障碍有效。TD-GCBT在治疗后至少九个月内有效缓解抑郁和焦虑症状。结果表明,TD-GCBT是一种具有成本效益和资源效益的策略,可作为治疗精神障碍的替代疗法。

临床试验注册

[https://www.chictr.org.cn],标识符[ChiCTR1900021806]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f427/9732091/f44707d858c4/fpsyt-13-1027994-g001.jpg

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