Hernández-Echevarría Odelaisys, Cuétara-Lugo Elizabeth Bárbara, Pérez-Benítez Mario Jesús, González-Gómez Julio César, González-Diez Héctor Raúl, Mendoza-Santiesteban Carlos E
Department of Neuro-ophthalmology, Cuban Institute of Ophthalmology "Ramón Pando Ferrer", University of Medical Sciences of Havana, Havana, Cuba.
Department of Research and Academic, National Institute of Oncology and Radiobiology, University of Medical Sciences of Havana, Havana, Cuba.
Front Integr Neurosci. 2022 Nov 24;16:1034705. doi: 10.3389/fnint.2022.1034705. eCollection 2022.
The study aimed to evaluate the retinal ganglion cell structure using optical coherence tomography and the visual pathway function employing visual evoked potentials in the diagnosis and monitoring of patients with pituitary macroadenoma. A descriptive, cross-sectional, and longitudinal study (3 and 12 months follow-up) was conducted on forty-two patients. Thirty-five age-matched healthy controls were used in the cross-sectional one. Full neuro-ophthalmological evaluation (structural and functional) was carried out including global and segmented retinal nerve fiber layer/ganglion cell complex analysis and amplitude and latency of P100 component in the electrophysiology. Statistical data analysis was conducted with R version 3.6.3 and Python version 3.8. Associations were evaluated using Spearman's correlations. Amplitude sensitivities were 0.999, and bi-nasal sectors of ganglion cell complex thickness specificities were 0.999. This structural parameter had the highest diagnostic value (area under curve = 0.923). Significant associations were found between bi-nasal sectors with amplitude at 12' (rho > 0.7, < 0.01) and median deviation of the visual field (rho > 0.5, < 0.01) at 3 months. Pre-surgical values of bi-nasal sectors and amplitude can predict post-surgically median deviation and amplitude (Oz, 12') at 3 months with > 0.5. Bi-nasal sectors of ganglion cell complex and visual evoked potentials P100 amplitude are efficient biomarkers of visual pathway damage for pituitary macroadenoma patients' management. Pre-surgical values of the bi-nasal sector and visual evoked potentials' amplitude could help to predict the restoration of parvocellular pathway traffic after decompression.
该研究旨在利用光学相干断层扫描评估视网膜神经节细胞结构，并采用视觉诱发电位评估视觉通路功能，以用于垂体大腺瘤患者的诊断和监测。对42例患者进行了一项描述性、横断面和纵向研究（随访3个月和12个月）。横断面研究中使用了35名年龄匹配的健康对照。进行了全面的神经眼科评估（结构和功能），包括整体和分段视网膜神经纤维层/神经节细胞复合体分析以及电生理中P100成分的波幅和潜伏期。使用R 3.6.3版本和Python 3.8版本进行统计数据分析。使用Spearman相关性评估关联。波幅敏感性为0.999，神经节细胞复合体厚度的双鼻侧扇形区域特异性为0.999。该结构参数具有最高的诊断价值（曲线下面积 = 0.923）。在3个月时，发现双鼻侧扇形区域与12'处的波幅（rho > 0.7，P < 0.01）和视野的平均偏差（rho > 0.5，P < 0.01）之间存在显著关联。双鼻侧扇形区域和波幅的术前值可以预测术后3个月时的平均偏差和波幅（12'处），rho > 0.5。神经节细胞复合体的双鼻侧扇形区域和视觉诱发电位P100波幅是垂体大腺瘤患者视觉通路损伤管理的有效生物标志物。双鼻侧扇形区域和视觉诱发电位波幅的术前值有助于预测减压后小细胞通路交通的恢复情况。
