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坏血病:与多种营养素缺乏相关的罕见骨科并发症

Scurvy: Rare Orthopaedic Complications Associated with Multinutritional Deficiencies.

作者信息

Carroll Melissa, Yoon Joseph, Elliot Patrick

机构信息

The Royal Darwin Hospital, Tiwi, Northern Territory, Australia.

出版信息

Eur J Case Rep Intern Med. 2022 Nov 17;9(11):003359. doi: 10.12890/2022_003359. eCollection 2022.

Abstract

UNLABELLED

Suboptimal nutrition can lead to deficiencies in micronutrients such as ascorbic acid (vitamin C), which can present with catastrophic neurological sequelae. Deficiencies of vitamin C, vitamin B3 (niacin) and zinc levels contribute to reduced bone density. Vitamin C associated vertebral fractures, although rare in adults, are still treatable if diagnosed early with a thorough clinical and nutritional history, and early supplementation. Radiological clues suggestive of scurvy-induced vertebral fractures can be diagnosed on plain X-ray and MRI spine imaging.

LEARNING POINTS

Although nutritional deficits like scurvy, pellagra and zinc deficiency are rare, early recognition and prompt treatment can prevent critical neurological sequelae.Clinical history including nutritional intake and associated patient symptoms are vital to diagnose scurvy-related vertebral fractures, which are treatable.It is important to note that scurvy can also present in an adult population.

摘要

未标注

营养状况欠佳会导致维生素C(抗坏血酸)等微量营养素缺乏,进而引发灾难性的神经后遗症。维生素C、维生素B3(烟酸)缺乏以及锌含量降低会导致骨密度下降。维生素C相关的椎体骨折在成年人中虽罕见,但如果通过全面的临床和营养病史早期诊断并尽早补充维生素C,仍可治愈。通过脊柱X线平片和磁共振成像(MRI)可发现提示坏血病所致椎体骨折的影像学线索。

学习要点

尽管坏血病、糙皮病和锌缺乏等营养缺乏症较为罕见,但早期识别和及时治疗可预防严重的神经后遗症。包括营养摄入情况及相关患者症状的临床病史对于诊断可治愈的坏血病相关椎体骨折至关重要。需要注意的是,坏血病也可能出现在成年人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db1/9728213/708fe8d44ae0/3359_Fig1.jpg

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