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杏仁核-脑岛-内侧前额叶皮质-外侧前额叶皮质通路及其紊乱

The amygdala-insula-medial prefrontal cortex-lateral prefrontal cortex pathway and its disorders.

作者信息

Ben Shalom Dorit

机构信息

School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beersheba, Israel.

出版信息

Front Neuroanat. 2022 Nov 24;16:1028546. doi: 10.3389/fnana.2022.1028546. eCollection 2022.

Abstract

Smith and Lane have suggested a model of emotion processing with at least three stations: areas like the amygdala, which process discrete body features areas like the anterior insula, which process whole-body patterns and areas like the medial prefrontal cortex, which process emotion concepts. Ben Shalom and Bonneh have suggested a model of the prefrontal cortex, in which medial BA 9 integrates emotional states, and lateral BA 9 performs selection/inhibition on these states. Taken together, the current paper suggests a pathway for emotion processing with at least four stations: areas like the amygdala, which process discrete body features areas like the anterior insula, which process whole-body patterns, medial BA 9 which integrates emotion concepts, and lateral BA 9, which performs selection/inhibition on these concepts. Following the existing literature, it then suggest that there is a significant involvement of the amygdala in psychopathy (Blair), of the anterior insula in alexithymia (Bird), of the medial BA 9 in deficits in somatosensory discrimination (Ben Shalom), and of lateral BA 9 in emotional impulsivity (Ronel).

摘要

史密斯和莱恩提出了一种情绪处理模型,该模型至少有三个处理站:像杏仁核这样的区域,处理离散的身体特征;像前脑岛这样的区域,处理全身模式;以及像内侧前额叶皮质这样的区域,处理情绪概念。本·沙洛姆和博内提出了一种前额叶皮质模型,其中内侧的9区整合情绪状态,外侧的9区对这些状态进行选择/抑制。综合来看,本文提出了一条至少有四个处理站的情绪处理途径:像杏仁核这样的区域,处理离散的身体特征;像前脑岛这样的区域,处理全身模式;内侧的9区,整合情绪概念;以及外侧的9区,对这些概念进行选择/抑制。接着,按照现有文献,本文指出杏仁核在精神病态中(布莱尔)、前脑岛在述情障碍中(伯德)、内侧9区在体感辨别缺陷中(本·沙洛姆)以及外侧9区在情绪冲动中(罗内尔)都有显著参与。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ce/9729692/78a72d5d4c2a/fnana-16-1028546-g001.jpg

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