Zhu Changchun, Jiang Jin, Feng Guoxing, Fan Saijun
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, 300192, Tianjin, PR China.
Mol Biol Rep. 2023 Feb;50(2):1829-1843. doi: 10.1007/s11033-022-07966-1. Epub 2022 Dec 12.
Radiation therapy is a commonly used tool in cancer management due to its ability to destroy malignant tumors. Mechanically, the efficacy of radiotherapy mainly depends on the inherent radiosensitivity of cancer cells and surrounding normal tissues, which mostly accounts for molecular dynamics associated with radiation-induced DNA damage. However, the relationship between radiosensitivity and DNA damage mechanism deserves to be further probed. As the well-established RNA regulators or effectors, long noncoding RNAs (lncRNAs) dominate vital roles in modulating ionizing radiation response by targeting crucial molecular pathways, including DNA damage repair. Recently, emerging evidence has constantly confirmed that overexpression or inhibition of lncRNAs can greatly influence the sensitivity of radiotherapy for many kinds of cancers, by driving a diverse array of DNA damage-associated signaling cascades. In conclusion, this review critically summarizes the recent progress in the molecular mechanism of IR-responsive lncRNAs in the context of radiation-induced DNA damage. The different response of lncRNAs when IR exposure. IR exposure can trigger the changes in expression pattern and subcellular localization of lncRNAs that influences the different radiology processes.
放射治疗因其能够破坏恶性肿瘤，是癌症治疗中常用的手段。从机制上讲，放射治疗的疗效主要取决于癌细胞和周围正常组织的固有放射敏感性，这主要与辐射诱导的DNA损伤相关的分子动力学有关。然而，放射敏感性与DNA损伤机制之间的关系值得进一步探究。作为公认的RNA调节因子或效应器，长链非编码RNA（lncRNA）通过靶向关键分子途径（包括DNA损伤修复），在调节电离辐射反应中起重要作用。最近，越来越多的证据不断证实，lncRNA的过表达或抑制可通过驱动多种与DNA损伤相关的信号级联反应，极大地影响多种癌症放疗的敏感性。总之，本综述批判性地总结了辐射诱导DNA损伤背景下IR反应性lncRNA分子机制的最新进展。IR暴露时lncRNA的不同反应。IR暴露可引发lncRNA表达模式和亚细胞定位的变化，从而影响不同的放射学过程。
