Department of Oncology, Medical College of Nantong University, Nantong, 226001 Jiangsu, China.
Department of Radiology, The First People's Hospital of Yancheng, Yancheng, 224006 Jiangsu, China.
Anal Cell Pathol (Amst). 2021 Sep 20;2021:9005073. doi: 10.1155/2021/9005073. eCollection 2021.
Breast cancer (BRCA) has severely threatened women's health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the knowledge on the classification and function of lncRNAs and the molecular mechanism of BRCA radioresistance, listed lncRNAs related to the BRCA radioresistance, highlighted their underlying mechanisms, and discussed the potential application of these lncRNAs in regulating BRCA radioresistance.
乳腺癌（BRCA）已严重威胁全球女性健康。放射治疗是 BRCA 的一种治疗方法，它应用高剂量的电离辐射诱导癌细胞死亡，降低疾病复发率。放射抵抗性是影响放射治疗疗效的最重要因素之一。长链非编码 RNA（lncRNA）被认为在调节 BRCA 的生物学行为中发挥着关键作用。目前，一些研究表明，lncRNA 的过表达或抑制可以极大地改变 BRCA 的放射抵抗性。在这篇综述中，我们总结了 lncRNA 的分类和功能以及 BRCA 放射抵抗性的分子机制方面的知识，列出了与 BRCA 放射抵抗性相关的 lncRNA，强调了它们的潜在机制，并讨论了这些 lncRNA 调节 BRCA 放射抵抗性的潜在应用。
