Gurin N G, Chizhevskaia V S, Kontsevaia N S
Antibiotiki. 1978 Dec;23(12):1102-8.
The experiment included 109 patients with non-specific pathological processes in the lungs. i.e. 21 cases with acute and 55 cases with chronic pneumonia and 33 cases with bronchial asthma with or without chronic pneumonia. Clinically intolerance of the antibacterial drugs was observed in 39 patients and increased leucolysis (above 15 per cent) was observed sometimes more frequently. Only with the use of penicillin the difference was 1.6 times. Out of 39 patients with clinical signs of allergy to antibiotics or sulphanilamide only 20 showed the signs of increased leucolysis on the use of the respective drug. No correlation between the percentage of the leucolysis cases due to antibiotics or sulphanilamides and the clinical signs of their intolerance was observed. The use of such drugs by a person or even only his presence in the hospital often induced increased leucolysis which may be considered as an indication of the person sensibilization to them.
该实验纳入了109例肺部有非特异性病理过程的患者，即21例急性肺炎患者、55例慢性肺炎患者以及33例伴有或不伴有慢性肺炎的支气管哮喘患者。临床上观察到39例患者对抗菌药物不耐受，有时白细胞溶解增加（超过15%）的情况更为频繁。仅使用青霉素时，差异为1.6倍。在39例有抗生素或磺胺类药物临床过敏体征的患者中，只有20例在使用相应药物时出现白细胞溶解增加的体征。未观察到抗生素或磺胺类药物导致的白细胞溶解病例百分比与其不耐受临床体征之间的相关性。一个人使用此类药物，甚至仅仅是其出现在医院，往往就会导致白细胞溶解增加，这可被视为该人对它们致敏的一种迹象。
