Yang Yanyan, Shen Tengqun, Li Mengfan, Leng Bing, Yao Ran, Gao Yanling, Sun Hairong, Li Zhenguang, Zhang Jinbiao
Weifang Medical University, Weifang, Shandong, China; Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong 264200, China.
Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong 264200, China.
Neurosci Lett. 2023 Jan 18;794:137010. doi: 10.1016/j.neulet.2022.137010. Epub 2022 Dec 9.
The complement system plays a crucial role in cognitive impairment in obstructive sleep apnea (OSA). The present study aimed to investigate the connections between complement component 8 gamma (C8G) levels in astrocyte-derived exosomes (ADEs) and cognitive impairment in OSA patients without dementia. This cross-sectional cohort study recruited 274 participants without dementia, including 124 OSA patients with mild cognitive impairment (MCI), 100 OSA patients without MCI, and 50 healthy control subjects. Enrolled participants underwent polysomnography (PSG) evaluation, neuropsychological scale assessment, magnetic resonance imaging scanning, and collection of peripheral blood samples for quantification of complement proteins in ADEs. The findings showed higher C8G concentrations in ADEs from OSA patients with MCI than in the controls and OSA without MCI group. Logistic regression analysis suggested that C8G levels in ADEs were independently associated with MCI in OSA patients. Multivariable linear regression analysis demonstrated that C8G levels in ADEs were significantly correlated with global cognitive scores and all cognitive subdomain scores after adjusting for demographic factors (age, sex, education), vascular risk factors (Body mass index, history of hypertension, diabetes, dyslipidemia), depressive symptoms measures, and apnea-hypopnea index (AHI) values. The levels of C8G were linearly positively related to the white matter hyperintensity (WMH) volumes in Pearson's correlation analysis. Our research confirmed that C8G levels are significantly associated with cognitive impairment in OSA patients, which paves the way for novel therapeutic targets for neurocognitive dysfunction progression in OSA patients in the future.
补体系统在阻塞性睡眠呼吸暂停（OSA）所致认知障碍中起关键作用。本研究旨在探讨星形胶质细胞衍生外泌体（ADEs）中的补体成分8γ（C8G）水平与无痴呆的OSA患者认知障碍之间的联系。这项横断面队列研究招募了274名无痴呆的参与者，包括124名患有轻度认知障碍（MCI）的OSA患者、100名无MCI的OSA患者和50名健康对照者。纳入的参与者接受了多导睡眠图（PSG）评估、神经心理量表评估、磁共振成像扫描，并采集外周血样本以定量ADEs中的补体蛋白。研究结果显示，患有MCI的OSA患者的ADEs中C8G浓度高于对照组和无MCI的OSA组。逻辑回归分析表明，ADEs中的C8G水平与OSA患者的MCI独立相关。多变量线性回归分析表明，在调整了人口统计学因素（年龄、性别、教育程度）、血管危险因素（体重指数、高血压病史、糖尿病、血脂异常）、抑郁症状测量指标和呼吸暂停低通气指数（AHI）值后，ADEs中的C8G水平与总体认知评分和所有认知子领域评分显著相关。在Pearson相关性分析中，C8G水平与白质高信号（WMH）体积呈线性正相关。我们的研究证实，C8G水平与OSA患者的认知障碍显著相关，这为未来OSA患者神经认知功能障碍进展的新型治疗靶点铺平了道路。
