疫苗预防 COVID-19 住院的有效性：基于多中心医院的病例对照研究，德国，2021 年 6 月至 2022 年 1 月。

Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022.

机构信息

Department for Infectious Disease Epidemiology, Immunization Unit, Robert Koch Institute, Germany.

出版信息

Vaccine. 2023 Jan 9;41(2):290-293. doi: 10.1016/j.vaccine.2022.11.065. Epub 2022 Dec 2.

DOI:10.1016/j.vaccine.2022.11.065

PMID:36509640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9715487/

Abstract

We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization during the Delta-variant dominance. The two-dose VE was 89 % (95 % CI 84-93 %) overall, 79 % in patients with more than two comorbidities and 77 % in adults aged 60-75 years. A third dose increased the VE to more than 93 % in all patient-subgroups.

摘要

我们在德国开展了一项前瞻性招募的多中心匹配病例对照研究，纳入了 852 名患者，以评估在德尔塔变异株流行期间，疫苗预防 COVID-19 相关住院的有效性（VE）。总体而言，两剂疫苗的 VE 为 89%（95%CI84-93%），在合并症超过两种的患者中为 79%，在 60-75 岁的成年人中为 77%。第三剂疫苗在所有患者亚组中的 VE 均提高至 93%以上。