Dolganova Irina N, Zotov Arsen K, Safonova Larisa P, Aleksandrova Polina V, Reshetov Igor V, Zaytsev Kirill I, Tuchin Valery V, Kurlov Vladimir N
Osipyan Institute of Solid State Physics of the Russian Academy of Sciences, Chernogolovka, Russia.
Bauman Moscow State Technical University, Moscow, Russia.
J Biophotonics. 2023 Mar;16(3):e202200288. doi: 10.1002/jbio.202200288. Epub 2022 Dec 20.
This article describes a sapphire cryoprobe as a promising solution to the significant problem of modern cryosurgery that is the monitoring of tissue freezing. This probe consists of a sapphire rod manufactured by the edge-defined film-fed growth technique from Al O melt and optical fibers accommodated inside the rod and connected to the source and the detector. The probe's design enables detection of spatially resolved diffuse reflected intensities of tissue optical response, which are used for the estimation of tissue freezing depth. The current type of the 12.5-mm diameter sapphire probe cooled down by the liquid nitrogen assumes a superficial cryoablation. The experimental test made by using a gelatin-intralipid tissue phantom shows the feasibility of such concept, revealing the capabilities of monitoring the freezing depth up to 10 mm by the particular instrumentation realization of the probe. This justifies a potential of sapphire-based instruments aided by optical diagnosis in modern cryosurgery.
本文介绍了一种蓝宝石冷冻探头，它有望解决现代冷冻手术中的一个重大问题，即组织冷冻监测。该探头由一根蓝宝石棒组成，该蓝宝石棒采用边缘限定膜进给生长技术由氧化铝熔体制造而成，光纤置于棒内并与光源和探测器相连。探头的设计能够检测组织光学响应的空间分辨漫反射强度，这些强度用于估计组织冷冻深度。目前直径为12.5毫米的蓝宝石探头由液氮冷却，适用于表面冷冻消融。使用明胶-脂质组织模型进行的实验测试表明了这种概念的可行性，通过探头的特定仪器实现揭示了监测高达10毫米冷冻深度的能力。这证明了在现代冷冻手术中基于蓝宝石的仪器借助光学诊断的潜力。
