扭转平衡：对癌症基质调控的新见解。

Tipping the balance: New insights into stromal regulation of cancer.

作者信息

Castro Joana Leitão, Erler Janine Terra

机构信息

Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

出版信息

Cancer Cell. 2022 Dec 12;40(12):1467-1469. doi: 10.1016/j.ccell.2022.11.011.

DOI:10.1016/j.ccell.2022.11.011

PMID:36513048

Abstract

Desmoplastic extracellular matrix (ECM) exerts a seemingly paradoxical role in cancer, restricting or promoting progression. Two recent back-to-back Nature reports shed light on this conundrum, revealing the role of different hepatic stellate cell (HSC) populations and different collagen I cleavage states in directing the progression of cancer.

摘要

促结缔组织增生性细胞外基质（ECM）在癌症中发挥着看似矛盾的作用，既限制癌症进展，又促进癌症进展。《自然》杂志最近相继发表的两篇报告揭示了这一难题，阐明了不同肝星状细胞（HSC）群体以及不同I型胶原蛋白裂解状态在引导癌症进展中的作用。