Al-Awsi Ghaidaa Raheem Lateef, Jasim Saade Abdalkareem, Fakri Mustafa Yasser, Alhachami Firas Rahi, Ziyadullaev Shukhrat, Kandeel Mahmoud, Abulkassim Roua, Sivaraman R, M Hameed Noora, Mireya Romero Parra Rosario, Karampoor Sajad, Mirzaei Rasoul
Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Iraq.
Department of Medical Laboratory Techniques, Al-maarif University College, Al-Anbar-Ramadi, Iraq.
Future Oncol. 2022 Dec;18(38):4209-4231. doi: 10.2217/fon-2022-0574. Epub 2022 Dec 15.
Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.
越来越多的数据表明各种微小RNA（miRNA）在恶性肿瘤中具有重要意义。在这方面，与miRNA-128（miR-128）在正常组织中的生物学作用相似，它在癌症发生和发展过程中发挥着重要的免疫调节功能。miR-128在肿瘤中异常表达的出现以及miRNA的独特特性，为其作为生物标志物和新一代分子抗癌疗法的应用带来了前景。本文综述了miR-128在乳腺癌、前列腺癌、结直肠癌、胃癌、胰腺癌、食管癌、宫颈癌、卵巢癌、膀胱癌和肝细胞癌等恶性肿瘤中的作用。最后，强调了外泌体miR-128对某些恶性肿瘤中癌症治疗耐药性和癌症免疫治疗的影响。
